DL-3-n-Butylphthalide Protects Against PrP106 -126-Induced Neurotoxicity Through NRF2 Signaling and OPA1/DRP1-Mediated Mitochondrial Dynamics.

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Title: DL-3-n-Butylphthalide Protects Against PrP106 -126-Induced Neurotoxicity Through NRF2 Signaling and OPA1/DRP1-Mediated Mitochondrial Dynamics.
Authors: Wu W; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.; Department of Basic Research, Guangzhou National Laboratory, Guangzhou, Guangdong, China.; Center for Neurometabolism and Regenerative Medicine, Bioland Laboratory, Guangzhou, Guangdong, China.; The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong, China., Zhang X; Department of Basic Research, Guangzhou National Laboratory, Guangzhou, Guangdong, China.; Center for Neurometabolism and Regenerative Medicine, Bioland Laboratory, Guangzhou, Guangdong, China., Jiang M; Department of Basic Research, Guangzhou National Laboratory, Guangzhou, Guangdong, China.; Center for Neurometabolism and Regenerative Medicine, Bioland Laboratory, Guangzhou, Guangdong, China., Ma N; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.; Department of Basic Research, Guangzhou National Laboratory, Guangzhou, Guangdong, China.; Center for Neurometabolism and Regenerative Medicine, Bioland Laboratory, Guangzhou, Guangdong, China.; The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong, China.
Source: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2026 Jun; Vol. 32 (6), pp. e70948.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE
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  Data: DL-3-n-Butylphthalide Protects Against PrP<superscript>106</superscript> <superscript>-126</superscript>-Induced Neurotoxicity Through NRF2 Signaling and OPA1/DRP1-Mediated Mitochondrial Dynamics.
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  Data: <searchLink fieldCode="AU" term="%22Wu+W%22">Wu W</searchLink>; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.; Department of Basic Research, Guangzhou National Laboratory, Guangzhou, Guangdong, China.; Center for Neurometabolism and Regenerative Medicine, Bioland Laboratory, Guangzhou, Guangdong, China.; The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Basic Research, Guangzhou National Laboratory, Guangzhou, Guangdong, China.; Center for Neurometabolism and Regenerative Medicine, Bioland Laboratory, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Jiang+M%22">Jiang M</searchLink>; Department of Basic Research, Guangzhou National Laboratory, Guangzhou, Guangdong, China.; Center for Neurometabolism and Regenerative Medicine, Bioland Laboratory, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Ma+N%22">Ma N</searchLink>; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.; Department of Basic Research, Guangzhou National Laboratory, Guangzhou, Guangdong, China.; Center for Neurometabolism and Regenerative Medicine, Bioland Laboratory, Guangzhou, Guangdong, China.; The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong, China.
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  Data: <searchLink fieldCode="JN" term="%22101473265%22">CNS neuroscience & therapeutics</searchLink> [CNS Neurosci Ther] 2026 Jun; Vol. 32 (6), pp. e70948.
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101473265 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1755-5949 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217555930%22">17555930 </searchLink><i>NLM ISO Abbreviation: </i>CNS Neurosci Ther <i>Subsets: </i>MEDLINE
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/cns.70948
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        Text: English
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      – TitleFull: DL-3-n-Butylphthalide Protects Against PrP106 -126-Induced Neurotoxicity Through NRF2 Signaling and OPA1/DRP1-Mediated Mitochondrial Dynamics.
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            NameFull: Wu W
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            NameFull: Zhang X
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            NameFull: Jiang M
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            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
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              Value: 32
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              Value: 6
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            – TitleFull: CNS neuroscience & therapeutics
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