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A Slc5a6-Deficient Mouse Model Reveals Metabolically Driven Cardiomyopathy with Therapeutic Potential for Vitamin-Based Intervention.

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Title: A Slc5a6-Deficient Mouse Model Reveals Metabolically Driven Cardiomyopathy with Therapeutic Potential for Vitamin-Based Intervention.
Authors: Fullerton MO; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Phillips LC; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Redgrave RE; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Spray L; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Haufroid V; Louvain Center for Toxicology and Applied Pharmacology (LTAP), UCLouvain, Brussels, Belgium., Merces G; Image Analysis Unit, Newcastle University, Newcastle upon Tyne, United Kingdom., Kerridge ST; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Richardson GD; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Mercier N; Department of Pediatrics, CHU HELORA Jo, La Louvière, Belgium., Roland D; Department of Human Genetics, Institute of Pathology and Genetics, Gosselies, Belgium., Crossley R; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Morgan AD; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Dewulf JP; Louvain Center for Toxicology and Applied Pharmacology (LTAP), UCLouvain, Brussels, Belgium., Burn J; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Bamforth SD; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Phillips HM; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Source: JCI insight [JCI Insight] 2026 Jun 02. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Fullerton+MO%22">Fullerton MO</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Phillips+LC%22">Phillips LC</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Redgrave+RE%22">Redgrave RE</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Spray+L%22">Spray L</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Haufroid+V%22">Haufroid V</searchLink>; Louvain Center for Toxicology and Applied Pharmacology (LTAP), UCLouvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Merces+G%22">Merces G</searchLink>; Image Analysis Unit, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kerridge+ST%22">Kerridge ST</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Richardson+GD%22">Richardson GD</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mercier+N%22">Mercier N</searchLink>; Department of Pediatrics, CHU HELORA Jo, La Louvière, Belgium.<br /><searchLink fieldCode="AU" term="%22Roland+D%22">Roland D</searchLink>; Department of Human Genetics, Institute of Pathology and Genetics, Gosselies, Belgium.<br /><searchLink fieldCode="AU" term="%22Crossley+R%22">Crossley R</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Morgan+AD%22">Morgan AD</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dewulf+JP%22">Dewulf JP</searchLink>; Louvain Center for Toxicology and Applied Pharmacology (LTAP), UCLouvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Burn+J%22">Burn J</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bamforth+SD%22">Bamforth SD</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Phillips+HM%22">Phillips HM</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
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              Text: 2026 Jun 02
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