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Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.

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Title: Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.
Authors: Morato NM; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907., Feng Y; Department of Chemistry, Purdue University, West Lafayette, IN 47907.; Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907., Chen K; Department of Chemistry, Purdue University, West Lafayette, IN 47907., Huang KH; Department of Chemistry, Purdue University, West Lafayette, IN 47907., Owen A; Department of Chemistry, Purdue University, West Lafayette, IN 47907., Caruso JV; Department of Chemistry, Purdue University, West Lafayette, IN 47907., Yang B; Department of Biochemistry, Purdue University, West Lafayette, IN 47907., Kulathunga SC; Department of Chemistry, Purdue University, West Lafayette, IN 47907., Mesecar AD; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907.; Department of Chemistry, Purdue University, West Lafayette, IN 47907.; Department of Biochemistry, Purdue University, West Lafayette, IN 47907., Klumpp-Thomas C; National Center for Advancing Translational Sciences, Rockville, MD 20850., Radujevic A; National Center for Advancing Translational Sciences, Rockville, MD 20850., Godfrey AG; National Center for Advancing Translational Sciences, Rockville, MD 20850., Gardner S; National Center for Advancing Translational Sciences, Rockville, MD 20850., Rudnicki DD; National Center for Advancing Translational Sciences, Rockville, MD 20850., Galbraith M; Hamilton Company, Reno, NV 89502., Gloeckner A; Hamilton Company, Reno, NV 89502., Hajdu C; Waters Corporation, Wilmslow SK9 4AX, United Kingdom., Pringle SD; Waters Corporation, Wilmslow SK9 4AX, United Kingdom., Morris M; Waters Corporation, Wilmslow SK9 4AX, United Kingdom., Balog J; Waters Corporation, Cambridge, MA 02142., Cooks RG; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907.; Department of Chemistry, Purdue University, West Lafayette, IN 47907.; Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 09; Vol. 123 (23), pp. e2536552123. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Morato+NM%22">Morato NM</searchLink>; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; Department of Chemistry, Purdue University, West Lafayette, IN 47907.; Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Department of Chemistry, Purdue University, West Lafayette, IN 47907.<br /><searchLink fieldCode="AU" term="%22Huang+KH%22">Huang KH</searchLink>; Department of Chemistry, Purdue University, West Lafayette, IN 47907.<br /><searchLink fieldCode="AU" term="%22Owen+A%22">Owen A</searchLink>; Department of Chemistry, Purdue University, West Lafayette, IN 47907.<br /><searchLink fieldCode="AU" term="%22Caruso+JV%22">Caruso JV</searchLink>; Department of Chemistry, Purdue University, West Lafayette, IN 47907.<br /><searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; Department of Biochemistry, Purdue University, West Lafayette, IN 47907.<br /><searchLink fieldCode="AU" term="%22Kulathunga+SC%22">Kulathunga SC</searchLink>; Department of Chemistry, Purdue University, West Lafayette, IN 47907.<br /><searchLink fieldCode="AU" term="%22Mesecar+AD%22">Mesecar AD</searchLink>; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907.; Department of Chemistry, Purdue University, West Lafayette, IN 47907.; Department of Biochemistry, Purdue University, West Lafayette, IN 47907.<br /><searchLink fieldCode="AU" term="%22Klumpp-Thomas+C%22">Klumpp-Thomas C</searchLink>; National Center for Advancing Translational Sciences, Rockville, MD 20850.<br /><searchLink fieldCode="AU" term="%22Radujevic+A%22">Radujevic A</searchLink>; National Center for Advancing Translational Sciences, Rockville, MD 20850.<br /><searchLink fieldCode="AU" term="%22Godfrey+AG%22">Godfrey AG</searchLink>; National Center for Advancing Translational Sciences, Rockville, MD 20850.<br /><searchLink fieldCode="AU" term="%22Gardner+S%22">Gardner S</searchLink>; National Center for Advancing Translational Sciences, Rockville, MD 20850.<br /><searchLink fieldCode="AU" term="%22Rudnicki+DD%22">Rudnicki DD</searchLink>; National Center for Advancing Translational Sciences, Rockville, MD 20850.<br /><searchLink fieldCode="AU" term="%22Galbraith+M%22">Galbraith M</searchLink>; Hamilton Company, Reno, NV 89502.<br /><searchLink fieldCode="AU" term="%22Gloeckner+A%22">Gloeckner A</searchLink>; Hamilton Company, Reno, NV 89502.<br /><searchLink fieldCode="AU" term="%22Hajdu+C%22">Hajdu C</searchLink>; Waters Corporation, Wilmslow SK9 4AX, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pringle+SD%22">Pringle SD</searchLink>; Waters Corporation, Wilmslow SK9 4AX, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Morris+M%22">Morris M</searchLink>; Waters Corporation, Wilmslow SK9 4AX, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Balog+J%22">Balog J</searchLink>; Waters Corporation, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Cooks+RG%22">Cooks RG</searchLink>; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907.; Department of Chemistry, Purdue University, West Lafayette, IN 47907.; Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907.
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