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Final outcomes of the SOFT and TEXT phase III trials in premenopausal hormone receptor-positive early breast cancer.

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Title: Final outcomes of the SOFT and TEXT phase III trials in premenopausal hormone receptor-positive early breast cancer.
Authors: Francis PA; Peter MacCallum Cancer Centre, Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia; Breast Cancer Trials Australia & New Zealand, Newcastle, Australia; International Breast Cancer Study Group, A Division of ETOP IBCSG Partners Foundation, Bern, Switzerland. Electronic address: prue.francis@petermac.org., Pagani O; Geneva University Hospitals, Geneva, Switzerland; University Hospitals, Lugano University, Lugano, Switzerland; Swiss Cancer Institute (Formerly SAKK), Bern, Switzerland., Fleming GF; The University of Chicago Medical Center, Chicago, USA., Walley BA; University of Calgary and Canadian Cancer Trials Group, Calgary, AB, Canada., Colleoni M; Division of Medical Senology, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Rubovszky G; Department of Thoracic and Abdominal Tumors and Clinical Pharmacology, National Institute of Oncology, Budapest, Hungary., Tondini C; Carlo Tondini, MD Osp. Papa Giovanni XXIII, Bergamo, Italy., Ciruelos EM; Instituto de Investigacion Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain; SOLTI Breast Cancer Research Group, Barcelona, Spain., Gomez HL; Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru., Bonnefoi HR; Institut Bergonié Comprehensive Cancer Centre, Université de Bordeaux, INSERM U1312, Bordeaux, France; European Organisation for Research and Treatment of Cancer (EORTC), Paris, France., Burstein HJ; Susan F. Smith Center for Women's Cancers, Dana-Farber Cancer Institute, Boston, USA; Harvard Medical School, Boston, USA; Alliance for Clinical Trials in Oncology, Chicago, USA., Chini C; Department of Medical Oncology, Ospedale di Circolo e Fondazione, Lombardy, Italy., Puglisi F; Department of Medicine (DMED), University of Udine, Udine, Italy; Department of Medical Oncology, IRCCS, Centro di Riferimento Oncologico CRO di Aviano, Aviano, Italy., Spazzapan S; Department of Medical Oncology, IRCCS, Centro di Riferimento Oncologico CRO di Aviano, Aviano, Italy., Bernardo A; Medical Oncology Unit, ICS Maugeri-IRCCS, Pavia, Italy., Climent MA; SOLTI Breast Cancer Research Group, Barcelona, Spain; Instituto Valenciano de Oncologia, Valencia, Spain., Bellet M; SOLTI Breast Cancer Research Group, Barcelona, Spain; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain; Vall d'Hebron University Hospital, Barcelona, Spain., Ruhstaller T; Swiss Cancer Institute (Formerly SAKK), Bern, Switzerland; University of Basel, Basel, Switzerland., Bermejo B; SOLTI Breast Cancer Research Group, Barcelona, Spain; Department of Medical Oncology, Hospital Clínico Universitario de Valencia, INCLIVA, Medicine Department Universidad de Valencia, Valencia, Spain., Chia SKL; Division of Medical Oncology, The University of British Columbia, Vancouver, BC, Canada; British Columbia Cancer Agency, Vancouver, BC, Canada; Canadian Cancer Trials Group, Kingston, ON, Canada., Martino S; The Angeles Clinic and Research Institute and SWOG, Santa Monica, USA., Geyer CE; University of Pittsburgh School of Medicine UPMC Hillman Cancer Center, Pittsburgh, USA; NRG Oncology, Philadelphia, USA., Goetz MP; Alliance for Clinical Trials in Oncology, Chicago, USA; Mayo Clinic, Rochester, USA., Ingle JN; Alliance for Clinical Trials in Oncology, Chicago, USA; Mayo Clinic, Rochester, USA., Stearns V; Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical School, New York, USA., Davidson NE; Fred Hutchinson Cancer Center, University of Washington, Seattle, USA; ECOG-ACRIN, Philadelphia, USA., Le Du F; Department of Medical Oncology, Centre Eugène Marquis, Rennes, France., Müller B; Chilean Cooperative Group for Oncological Research (GOCCHI), Santiago, Chile., Coleman RE; Weston Park Hospital, Sheffield, UK; NCRI Breast Cancer Clinical Studies Group (NCRI-BCSG), London, UK; CR-CTSU, London, UK., Loibl S; Goethe University of Frankfurt, Frankfurt, Germany; German Breast Group, Neu-Isenburg, Germany., Winer EP; Yale Cancer Center, Yale School of Medicine, New Haven, USA., Ruepp B; ETOP IBCSG Partners Foundation Coordinating Center, Bern, Switzerland., Loi S; International Breast Cancer Study Group, A Division of ETOP IBCSG Partners Foundation, Bern, Switzerland; The Sir Peter MacCallum Department of Medical Oncology, The University of Melbourne, Parkville, Melbourne, Australia; Division of Cancer Research, Peter MacCallum Cancer Center, Melbourne, Australia., Láng I; Clinexpert-research, Budapest, Hungary., Coates AS; International Breast Cancer Study Group, A Division of ETOP IBCSG Partners Foundation, Bern, Switzerland; University of Sydney, Sydney, Australia., Gelber RD; Harvard Medical School, Boston, USA; International Breast Cancer Study Group Statistical Center, Dana-Farber Cancer Institute, Boston, USA; Department of Data Science, Division of Biostatistics, Dana-Farber Cancer Institute, Boston, USA; Harvard TH Chan School of Public Health, Boston, USA; Frontier Science Foundation, Boston, USA., Goldhirsch A; Harvard Medical School, Boston, USA; IEO, European Institute of Oncology, IRCCS, Milan, Italy., Regan MM; Harvard Medical School, Boston, USA; International Breast Cancer Study Group Statistical Center, Dana-Farber Cancer Institute, Boston, USA; Department of Data Science, Division of Biostatistics, Dana-Farber Cancer Institute, Boston, USA.
Corporate Authors: International Breast Cancer Study Group, SOFT and TEXT Investigators
Source: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2026 Jun 01. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Final outcomes of the SOFT and TEXT phase III trials in premenopausal hormone receptor-positive early breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Francis+PA%22">Francis PA</searchLink>; Peter MacCallum Cancer Centre, Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia; Breast Cancer Trials Australia & New Zealand, Newcastle, Australia; International Breast Cancer Study Group, A Division of ETOP IBCSG Partners Foundation, Bern, Switzerland. Electronic address: prue.francis@petermac.org.<br /><searchLink fieldCode="AU" term="%22Pagani+O%22">Pagani O</searchLink>; Geneva University Hospitals, Geneva, Switzerland; University Hospitals, Lugano University, Lugano, Switzerland; Swiss Cancer Institute (Formerly SAKK), Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fleming+GF%22">Fleming GF</searchLink>; The University of Chicago Medical Center, Chicago, USA.<br /><searchLink fieldCode="AU" term="%22Walley+BA%22">Walley BA</searchLink>; University of Calgary and Canadian Cancer Trials Group, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Colleoni+M%22">Colleoni M</searchLink>; Division of Medical Senology, IEO, European Institute of Oncology, IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rubovszky+G%22">Rubovszky G</searchLink>; Department of Thoracic and Abdominal Tumors and Clinical Pharmacology, National Institute of Oncology, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Tondini+C%22">Tondini C</searchLink>; Carlo Tondini, MD Osp. Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Ciruelos+EM%22">Ciruelos EM</searchLink>; Instituto de Investigacion Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain; SOLTI Breast Cancer Research Group, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gomez+HL%22">Gomez HL</searchLink>; Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru.<br /><searchLink fieldCode="AU" term="%22Bonnefoi+HR%22">Bonnefoi HR</searchLink>; Institut Bergonié Comprehensive Cancer Centre, Université de Bordeaux, INSERM U1312, Bordeaux, France; European Organisation for Research and Treatment of Cancer (EORTC), Paris, France.<br /><searchLink fieldCode="AU" term="%22Burstein+HJ%22">Burstein HJ</searchLink>; Susan F. Smith Center for Women's Cancers, Dana-Farber Cancer Institute, Boston, USA; Harvard Medical School, Boston, USA; Alliance for Clinical Trials in Oncology, Chicago, USA.<br /><searchLink fieldCode="AU" term="%22Chini+C%22">Chini C</searchLink>; Department of Medical Oncology, Ospedale di Circolo e Fondazione, Lombardy, Italy.<br /><searchLink fieldCode="AU" term="%22Puglisi+F%22">Puglisi F</searchLink>; Department of Medicine (DMED), University of Udine, Udine, Italy; Department of Medical Oncology, IRCCS, Centro di Riferimento Oncologico CRO di Aviano, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Spazzapan+S%22">Spazzapan S</searchLink>; Department of Medical Oncology, IRCCS, Centro di Riferimento Oncologico CRO di Aviano, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Bernardo+A%22">Bernardo A</searchLink>; Medical Oncology Unit, ICS Maugeri-IRCCS, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Climent+MA%22">Climent MA</searchLink>; SOLTI Breast Cancer Research Group, Barcelona, Spain; Instituto Valenciano de Oncologia, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Bellet+M%22">Bellet M</searchLink>; SOLTI Breast Cancer Research Group, Barcelona, Spain; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain; Vall d'Hebron University Hospital, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ruhstaller+T%22">Ruhstaller T</searchLink>; Swiss Cancer Institute (Formerly SAKK), Bern, Switzerland; University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bermejo+B%22">Bermejo B</searchLink>; SOLTI Breast Cancer Research Group, Barcelona, Spain; Department of Medical Oncology, Hospital Clínico Universitario de Valencia, INCLIVA, Medicine Department Universidad de Valencia, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Chia+SKL%22">Chia SKL</searchLink>; Division of Medical Oncology, The University of British Columbia, Vancouver, BC, Canada; British Columbia Cancer Agency, Vancouver, BC, Canada; Canadian Cancer Trials Group, Kingston, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Martino+S%22">Martino S</searchLink>; The Angeles Clinic and Research Institute and SWOG, Santa Monica, USA.<br /><searchLink fieldCode="AU" term="%22Geyer+CE%22">Geyer CE</searchLink>; University of Pittsburgh School of Medicine UPMC Hillman Cancer Center, Pittsburgh, USA; NRG Oncology, Philadelphia, USA.<br /><searchLink fieldCode="AU" term="%22Goetz+MP%22">Goetz MP</searchLink>; Alliance for Clinical Trials in Oncology, Chicago, USA; Mayo Clinic, Rochester, USA.<br /><searchLink fieldCode="AU" term="%22Ingle+JN%22">Ingle JN</searchLink>; Alliance for Clinical Trials in Oncology, Chicago, USA; Mayo Clinic, Rochester, USA.<br /><searchLink fieldCode="AU" term="%22Stearns+V%22">Stearns V</searchLink>; Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical School, New York, USA.<br /><searchLink fieldCode="AU" term="%22Davidson+NE%22">Davidson NE</searchLink>; Fred Hutchinson Cancer Center, University of Washington, Seattle, USA; ECOG-ACRIN, Philadelphia, USA.<br /><searchLink fieldCode="AU" term="%22Le+Du+F%22">Le Du F</searchLink>; Department of Medical Oncology, Centre Eugène Marquis, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Müller+B%22">Müller B</searchLink>; Chilean Cooperative Group for Oncological Research (GOCCHI), Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Coleman+RE%22">Coleman RE</searchLink>; Weston Park Hospital, Sheffield, UK; NCRI Breast Cancer Clinical Studies Group (NCRI-BCSG), London, UK; CR-CTSU, London, UK.<br /><searchLink fieldCode="AU" term="%22Loibl+S%22">Loibl S</searchLink>; Goethe University of Frankfurt, Frankfurt, Germany; German Breast Group, Neu-Isenburg, Germany.<br /><searchLink fieldCode="AU" term="%22Winer+EP%22">Winer EP</searchLink>; Yale Cancer Center, Yale School of Medicine, New Haven, USA.<br /><searchLink fieldCode="AU" term="%22Ruepp+B%22">Ruepp B</searchLink>; ETOP IBCSG Partners Foundation Coordinating Center, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Loi+S%22">Loi S</searchLink>; International Breast Cancer Study Group, A Division of ETOP IBCSG Partners Foundation, Bern, Switzerland; The Sir Peter MacCallum Department of Medical Oncology, The University of Melbourne, Parkville, Melbourne, Australia; Division of Cancer Research, Peter MacCallum Cancer Center, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Láng+I%22">Láng I</searchLink>; Clinexpert-research, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Coates+AS%22">Coates AS</searchLink>; International Breast Cancer Study Group, A Division of ETOP IBCSG Partners Foundation, Bern, Switzerland; University of Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Gelber+RD%22">Gelber RD</searchLink>; Harvard Medical School, Boston, USA; International Breast Cancer Study Group Statistical Center, Dana-Farber Cancer Institute, Boston, USA; Department of Data Science, Division of Biostatistics, Dana-Farber Cancer Institute, Boston, USA; Harvard TH Chan School of Public Health, Boston, USA; Frontier Science Foundation, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Goldhirsch+A%22">Goldhirsch A</searchLink>; Harvard Medical School, Boston, USA; IEO, European Institute of Oncology, IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Regan+MM%22">Regan MM</searchLink>; Harvard Medical School, Boston, USA; International Breast Cancer Study Group Statistical Center, Dana-Farber Cancer Institute, Boston, USA; Department of Data Science, Division of Biostatistics, Dana-Farber Cancer Institute, Boston, USA.
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