Adjunctive Mechanical Ventilation or Intravenous Hypertonic Saline in Malawian Children with Cerebral Malaria and Highly Increased Brain Volume: A Randomized, Phase 3 Clinical Trial.
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| Title: | Adjunctive Mechanical Ventilation or Intravenous Hypertonic Saline in Malawian Children with Cerebral Malaria and Highly Increased Brain Volume: A Randomized, Phase 3 Clinical Trial. |
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| Authors: | O'Brien NF; Division of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA. Nicole.OBrien@nationwidechildrens.org., Postels DG; Division of Neurology, George Washington University/ Children's National Hospital, Washington, DC, USA., Chimalizeni Y; Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Fonseca Y; Division of Critical Care, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA., Wooldridge G; Perth Children's Hospital, Perth, Australia., Parker E; Division of Critical Care, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA., Galeano X; Division of Pediatric Critical Care Medicine, Department of Pediatrics, Hospital Privado Salud Integral, Managua, Nicaragua., Urbina E; Division of Critical Care, Department of Pediatrics, Universidad Autónoma de Mexico, Mexico City, Mexico., Lintner-Rivera M; Division of Critical Care, Department of Pediatrics, University of Indiana, Bloomington, USA., Wynkoop HJ; Division of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA., Chetcuti K; Radiology Division, Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Goyal MS; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Biondo-Savin E; Department of Radiology, Michigan Institute for Neurological Disorders, Farmington Hills, USA., Juvvadi S; Tenet Diagnostics, Hyderabad, India., Nicholas J; Cincinnati Children's Hospital Medical Center, Department of Radiology, Cincinnati, OH, USA., Vidal L; Division of Neuroradiology, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Raees M; Division of Critical Care, Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Doctor A; Division of Critical Care, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA., Remy KE; School of Medicine, Washington University in St. Louis, St. Louis, MO., Department of Pediatrics, University Hospitals of Cleveland, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Bhutta A; Division of Critical Care, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA., Holloway A; Division of Critical Care, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA., Moxon CA; Center for Parasitology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Kamuzu University of Health Sciences, Blantyre, Malawi., Seydel KB; Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA., Liomba AM; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Chilingulo C; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Ibrahim K; Center for Food Allergy and Asthma Research (CFAAR), Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Gardiner J; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA., Taylor TE; Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA. |
| Source: | Neurocritical care [Neurocrit Care] 2026 Jun 02. Date of Electronic Publication: 2026 Jun 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Humana Press Country of Publication: United States NLM ID: 101156086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-0961 (Electronic) Linking ISSN: 15416933 NLM ISO Abbreviation: Neurocrit Care Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42230477 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Adjunctive Mechanical Ventilation or Intravenous Hypertonic Saline in Malawian Children with Cerebral Malaria and Highly Increased Brain Volume: A Randomized, Phase 3 Clinical Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22O'Brien+NF%22">O'Brien NF</searchLink>; Division of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA. Nicole.OBrien@nationwidechildrens.org.<br /><searchLink fieldCode="AU" term="%22Postels+DG%22">Postels DG</searchLink>; Division of Neurology, George Washington University/ Children's National Hospital, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Chimalizeni+Y%22">Chimalizeni Y</searchLink>; Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Fonseca+Y%22">Fonseca Y</searchLink>; Division of Critical Care, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wooldridge+G%22">Wooldridge G</searchLink>; Perth Children's Hospital, Perth, Australia.<br /><searchLink fieldCode="AU" term="%22Parker+E%22">Parker E</searchLink>; Division of Critical Care, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Galeano+X%22">Galeano X</searchLink>; Division of Pediatric Critical Care Medicine, Department of Pediatrics, Hospital Privado Salud Integral, Managua, Nicaragua.<br /><searchLink fieldCode="AU" term="%22Urbina+E%22">Urbina E</searchLink>; Division of Critical Care, Department of Pediatrics, Universidad Autónoma de Mexico, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Lintner-Rivera+M%22">Lintner-Rivera M</searchLink>; Division of Critical Care, Department of Pediatrics, University of Indiana, Bloomington, USA.<br /><searchLink fieldCode="AU" term="%22Wynkoop+HJ%22">Wynkoop HJ</searchLink>; Division of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Chetcuti+K%22">Chetcuti K</searchLink>; Radiology Division, Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Goyal+MS%22">Goyal MS</searchLink>; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Biondo-Savin+E%22">Biondo-Savin E</searchLink>; Department of Radiology, Michigan Institute for Neurological Disorders, Farmington Hills, USA.<br /><searchLink fieldCode="AU" term="%22Juvvadi+S%22">Juvvadi S</searchLink>; Tenet Diagnostics, Hyderabad, India.<br /><searchLink fieldCode="AU" term="%22Nicholas+J%22">Nicholas J</searchLink>; Cincinnati Children's Hospital Medical Center, Department of Radiology, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Vidal+L%22">Vidal L</searchLink>; Division of Neuroradiology, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Raees+M%22">Raees M</searchLink>; Division of Critical Care, Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Doctor+A%22">Doctor A</searchLink>; Division of Critical Care, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Remy+KE%22">Remy KE</searchLink>; School of Medicine, Washington University in St. Louis, St. Louis, MO., Department of Pediatrics, University Hospitals of Cleveland, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Bhutta+A%22">Bhutta A</searchLink>; Division of Critical Care, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA.<br /><searchLink fieldCode="AU" term="%22Holloway+A%22">Holloway A</searchLink>; Division of Critical Care, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Moxon+CA%22">Moxon CA</searchLink>; Center for Parasitology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Seydel+KB%22">Seydel KB</searchLink>; Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.<br /><searchLink fieldCode="AU" term="%22Liomba+AM%22">Liomba AM</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Chilingulo+C%22">Chilingulo C</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Ibrahim+K%22">Ibrahim K</searchLink>; Center for Food Allergy and Asthma Research (CFAAR), Northwestern University Feinberg School of Medicine, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Gardiner+J%22">Gardiner J</searchLink>; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+TE%22">Taylor TE</searchLink>; Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101156086%22">Neurocritical care</searchLink> [Neurocrit Care] 2026 Jun 02. <i>Date of Electronic Publication: </i>2026 Jun 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Humana+Press%22">Humana Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101156086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1556-0961 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215416933%22">15416933 </searchLink><i>NLM ISO Abbreviation: </i>Neurocrit Care <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42230477 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s12028-026-02540-0 Languages: – Code: eng Text: English Titles: – TitleFull: Adjunctive Mechanical Ventilation or Intravenous Hypertonic Saline in Malawian Children with Cerebral Malaria and Highly Increased Brain Volume: A Randomized, Phase 3 Clinical Trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: O'Brien NF – PersonEntity: Name: NameFull: Postels DG – PersonEntity: Name: NameFull: Chimalizeni Y – PersonEntity: Name: NameFull: Fonseca Y – PersonEntity: Name: NameFull: Wooldridge G – PersonEntity: Name: NameFull: Parker E – PersonEntity: Name: NameFull: Galeano X – PersonEntity: Name: NameFull: Urbina E – PersonEntity: Name: NameFull: Lintner-Rivera M – PersonEntity: Name: NameFull: Wynkoop HJ – PersonEntity: Name: NameFull: Chetcuti K – PersonEntity: Name: NameFull: Goyal MS – PersonEntity: Name: NameFull: Biondo-Savin E – PersonEntity: Name: NameFull: Juvvadi S – PersonEntity: Name: NameFull: Nicholas J – PersonEntity: Name: NameFull: Vidal L – PersonEntity: Name: NameFull: Raees M – PersonEntity: Name: NameFull: Doctor A – PersonEntity: Name: NameFull: Remy KE – PersonEntity: Name: NameFull: Bhutta A – PersonEntity: Name: NameFull: Holloway A – PersonEntity: Name: NameFull: Moxon CA – PersonEntity: Name: NameFull: Seydel KB – PersonEntity: Name: NameFull: Liomba AM – PersonEntity: Name: NameFull: Chilingulo C – PersonEntity: Name: NameFull: Ibrahim K – PersonEntity: Name: NameFull: Gardiner J – PersonEntity: Name: NameFull: Taylor TE IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 06 Text: 2026 Jun 02 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1556-0961 Titles: – TitleFull: Neurocritical care Type: main |
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