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USP2 is an androgen-repressed survival factor that stabilises oncoproteins to facilitate therapy resistance in prostate cancer.

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Title: USP2 is an androgen-repressed survival factor that stabilises oncoproteins to facilitate therapy resistance in prostate cancer.
Authors: Fang DM; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia., Shrestha RK; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Freemasons Centre for Male Health and Wellbeing, Flinders University, Bedford Park, SA, Australia., German B; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA.; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Rahman R; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Townley SL; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Xie J; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Freemasons Centre for Male Health and Wellbeing, Flinders University, Bedford Park, SA, Australia.; Guangdong Engineering Research Center of Low-Carbon Synthetic Biotechnology, School of Biology and Biological Engineering, South China University of Technology, University Town, Guangzhou, China., Hanson AR; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Iggo R; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.; Institut Bergonié, University of Bordeaux, INSERM, Bordeaux, France., Nassar ZD; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.; South Australian immunoGENomics Cancer Institute (SAiGENCI), University of Adelaide, Adelaide, SA, Australia., Helm M; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.; South Australian immunoGENomics Cancer Institute (SAiGENCI), University of Adelaide, Adelaide, SA, Australia., Marri S; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Colella AD; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Flinders Proteomics Facility, Flinders University, Bedford Park, SA, Australia., Best G; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Centenera MM; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.; South Australian immunoGENomics Cancer Institute (SAiGENCI), University of Adelaide, Adelaide, SA, Australia., Tilley WD; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia., Chataway TK; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Flinders Proteomics Facility, Flinders University, Bedford Park, SA, Australia., Ellis L; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA.; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Butler LM; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.; South Australian immunoGENomics Cancer Institute (SAiGENCI), University of Adelaide, Adelaide, SA, Australia., Selth LA; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia. luke.selth@flinders.edu.au.; Freemasons Centre for Male Health and Wellbeing, Flinders University, Bedford Park, SA, Australia. luke.selth@flinders.edu.au.; Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia. luke.selth@flinders.edu.au.
Source: Cell death & disease [Cell Death Dis] 2026 Jun 02. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Fang+DM%22">Fang DM</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Shrestha+RK%22">Shrestha RK</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Freemasons Centre for Male Health and Wellbeing, Flinders University, Bedford Park, SA, Australia.<br /><searchLink fieldCode="AU" term="%22German+B%22">German B</searchLink>; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA.; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rahman+R%22">Rahman R</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Townley+SL%22">Townley SL</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Freemasons Centre for Male Health and Wellbeing, Flinders University, Bedford Park, SA, Australia.; Guangdong Engineering Research Center of Low-Carbon Synthetic Biotechnology, School of Biology and Biological Engineering, South China University of Technology, University Town, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Hanson+AR%22">Hanson AR</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Iggo+R%22">Iggo R</searchLink>; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.; Institut Bergonié, University of Bordeaux, INSERM, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Nassar+ZD%22">Nassar ZD</searchLink>; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.; South Australian immunoGENomics Cancer Institute (SAiGENCI), University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Helm+M%22">Helm M</searchLink>; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.; South Australian immunoGENomics Cancer Institute (SAiGENCI), University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Marri+S%22">Marri S</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Colella+AD%22">Colella AD</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Flinders Proteomics Facility, Flinders University, Bedford Park, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Best+G%22">Best G</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Centenera+MM%22">Centenera MM</searchLink>; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.; South Australian immunoGENomics Cancer Institute (SAiGENCI), University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Tilley+WD%22">Tilley WD</searchLink>; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Chataway+TK%22">Chataway TK</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Flinders Proteomics Facility, Flinders University, Bedford Park, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Ellis+L%22">Ellis L</searchLink>; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA.; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Butler+LM%22">Butler LM</searchLink>; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.; South Australian immunoGENomics Cancer Institute (SAiGENCI), University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Selth+LA%22">Selth LA</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia. luke.selth@flinders.edu.au.; Freemasons Centre for Male Health and Wellbeing, Flinders University, Bedford Park, SA, Australia. luke.selth@flinders.edu.au.; Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia. luke.selth@flinders.edu.au.
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