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An integrative mendelian randomisation and drug mechanism framework for target prioritisation and therapeutic repurposing in major depression.

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Title: An integrative mendelian randomisation and drug mechanism framework for target prioritisation and therapeutic repurposing in major depression.
Authors: Ter Kuile AR; Department of Clinical, Educational and Health Psychology, University College London, London, UK. a.kuile@ucl.ac.uk., Finan C; Institute of Cardiovascular Science, University College London, London, UK.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK., Chopade S; Institute of Cardiovascular Science, University College London, London, UK., van Vugt M; Institute of Cardiovascular Science, University College London, London, UK.; Department of Cardiology, Division of Heart and Lungs, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, the Netherlands., Hukerikar N; Institute of Cardiovascular Science, University College London, London, UK.; Institute of Health Informatics, University College London, London, UK., Barral S; Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children, UCL GOS Institute of Child Health, University College London, London, UK., Stringaris A; Department of Clinical, Educational and Health Psychology, University College London, London, UK.; Division of Psychiatry, University College London, London, UK., Schmidt AF; Institute of Cardiovascular Science, University College London, London, UK.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, the Netherlands., Kuchenbaecker K; Division of Psychiatry, University College London, London, UK., Pingault JB; Department of Clinical, Educational and Health Psychology, University College London, London, UK. j.pingault@ucl.ac.uk.; Social Genetic and Developmental Psychiatry, King's College London, London, UK. j.pingault@ucl.ac.uk.
Source: Translational psychiatry [Transl Psychiatry] 2026 Jun 02. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ter+Kuile+AR%22">Ter Kuile AR</searchLink>; Department of Clinical, Educational and Health Psychology, University College London, London, UK. a.kuile@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Finan+C%22">Finan C</searchLink>; Institute of Cardiovascular Science, University College London, London, UK.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Chopade+S%22">Chopade S</searchLink>; Institute of Cardiovascular Science, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22van+Vugt+M%22">van Vugt M</searchLink>; Institute of Cardiovascular Science, University College London, London, UK.; Department of Cardiology, Division of Heart and Lungs, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hukerikar+N%22">Hukerikar N</searchLink>; Institute of Cardiovascular Science, University College London, London, UK.; Institute of Health Informatics, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Barral+S%22">Barral S</searchLink>; Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children, UCL GOS Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Stringaris+A%22">Stringaris A</searchLink>; Department of Clinical, Educational and Health Psychology, University College London, London, UK.; Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Schmidt+AF%22">Schmidt AF</searchLink>; Institute of Cardiovascular Science, University College London, London, UK.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kuchenbaecker+K%22">Kuchenbaecker K</searchLink>; Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pingault+JB%22">Pingault JB</searchLink>; Department of Clinical, Educational and Health Psychology, University College London, London, UK. j.pingault@ucl.ac.uk.; Social Genetic and Developmental Psychiatry, King's College London, London, UK. j.pingault@ucl.ac.uk.
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              Text: 2026 Jun 02
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