Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum.
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| Title: | Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum. |
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| Authors: | Perry TA; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK. thomas.perry@kennedy.ox.ac.uk., Deng Y; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK., Hulley PA; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Maciewicz RA; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK., Mitchelmore J; Novartis Biomedical Research, Basel, Switzerland., Larsson S; Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden., Gogain J; Standard BioTools (previously known as SomaLogic), Boulder, Colorado, USA., Brachat S; Novartis Biomedical Research, Basel, Switzerland., Struglics A; Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden., Appleton CT; Department of Medicine, University of Western Ontario, London, Ontario, Canada., Kluzek S; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; NIHR Nottingham Biomedical Research Centre and Versus Arthritis Sport, Exercise and Osteoarthritis Centre, University of Nottingham, Nottingham, UK., Arden NK; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Oxford, Oxford, UK., Felson D; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts, USA., Bondi L; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Kapoor M; Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada., Lohmander LS; Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden., Welting TJ; Laboratory for Experimental Orthopedics, Department of Orthopedic Surgery, Maastricht University, Maastricht, Netherlands., Walsh DA; Pain Centre Versus Arthritis, Advanced Pain Discovery Platform, and the NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.; Sherwood Forest Hospitals NHS Foundation Trust, Sutton in Ashfield, UK., Valdes AM; Pain Centre Versus Arthritis, Advanced Pain Discovery Platform, and the NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK., Jostins-Dean L; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK., Watt FE; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK., Tom BDM; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Vincent TL; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK. tonia.vincent@kennedy.ox.ac.uk. |
| Corporate Authors: | STEpUP OA Consortium |
| Source: | Nature communications [Nat Commun] 2026 Jun 02; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 02. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-71632-4 |
