Sphingosine kinase-2 inhibition promotes immunogenic differentiation of myeloid-derived suppressor cells through an Acetyl-CoA carboxylase-phosphatidylcholine axis.
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| Title: | Sphingosine kinase-2 inhibition promotes immunogenic differentiation of myeloid-derived suppressor cells through an Acetyl-CoA carboxylase-phosphatidylcholine axis. |
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| Authors: | Chakraborty P; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Chatterjee S; Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India., Kassir MF; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Wofford W; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Choi S; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Oleinik N; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Saatci O; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Darawshi O; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Das S; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Oberhoeltzer N; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Gautam A; Institute for Bioinformatics and Medical Informatics, University of Tübingen, Tübingen, Germany.; Max Planck Institute for Biology, Tübingen, Germany., Mills S; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., DeMass R; Public Health, Medical University of South Carolina, Charleston, South Carolina, USA., Hedley Z; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Liu Y; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Parikh RY; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Paul S; Center for Health Science and Technology, JIS Institute of Advanced Studies and Research, JIS University, Kolkata, India., Seal S; Public Health, Medical University of South Carolina, Charleston, South Carolina, USA., Smith CD; Apogee Biotechnology Corporation, Hummelstown, USA., Lilly MB; Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Gangaraju VK; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Peterson Y; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA., Mehrotra M; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA., Hill E; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Sahin O; Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India., Leitinger N; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA., Ogretmen B; Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India., Mehrotra S; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA. mehrotr@musc.edu. |
| Source: | Nature communications [Nat Commun] 2026 Jun 02; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42230631 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Sphingosine kinase-2 inhibition promotes immunogenic differentiation of myeloid-derived suppressor cells through an Acetyl-CoA carboxylase-phosphatidylcholine axis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chakraborty+P%22">Chakraborty P</searchLink>; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Chatterjee+S%22">Chatterjee S</searchLink>; Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.<br /><searchLink fieldCode="AU" term="%22Kassir+MF%22">Kassir MF</searchLink>; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Wofford+W%22">Wofford W</searchLink>; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Choi+S%22">Choi S</searchLink>; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Oleinik+N%22">Oleinik N</searchLink>; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Saatci+O%22">Saatci O</searchLink>; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Darawshi+O%22">Darawshi O</searchLink>; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Das+S%22">Das S</searchLink>; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Oberhoeltzer+N%22">Oberhoeltzer N</searchLink>; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Gautam+A%22">Gautam A</searchLink>; Institute for Bioinformatics and Medical Informatics, University of Tübingen, Tübingen, Germany.; Max Planck Institute for Biology, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Mills+S%22">Mills S</searchLink>; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22DeMass+R%22">DeMass R</searchLink>; Public Health, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Hedley+Z%22">Hedley Z</searchLink>; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Parikh+RY%22">Parikh RY</searchLink>; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Paul+S%22">Paul S</searchLink>; Center for Health Science and Technology, JIS Institute of Advanced Studies and Research, JIS University, Kolkata, India.<br /><searchLink fieldCode="AU" term="%22Seal+S%22">Seal S</searchLink>; Public Health, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Smith+CD%22">Smith CD</searchLink>; Apogee Biotechnology Corporation, Hummelstown, USA.<br /><searchLink fieldCode="AU" term="%22Lilly+MB%22">Lilly MB</searchLink>; Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Gangaraju+VK%22">Gangaraju VK</searchLink>; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Peterson+Y%22">Peterson Y</searchLink>; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Mehrotra+M%22">Mehrotra M</searchLink>; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Hill+E%22">Hill E</searchLink>; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Sahin+O%22">Sahin O</searchLink>; Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.<br /><searchLink fieldCode="AU" term="%22Leitinger+N%22">Leitinger N</searchLink>; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+PC%22">Rodriguez PC</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Ogretmen+B%22">Ogretmen B</searchLink>; Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.<br /><searchLink fieldCode="AU" term="%22Mehrotra+S%22">Mehrotra S</searchLink>; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA. mehrotr@musc.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jun 02; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Jun 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42230631 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-026-73827-1 Languages: – Code: eng Text: English Titles: – TitleFull: Sphingosine kinase-2 inhibition promotes immunogenic differentiation of myeloid-derived suppressor cells through an Acetyl-CoA carboxylase-phosphatidylcholine axis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chakraborty P – PersonEntity: Name: NameFull: Chatterjee S – PersonEntity: Name: NameFull: Kassir MF – PersonEntity: Name: NameFull: Wofford W – PersonEntity: Name: NameFull: Choi S – PersonEntity: Name: NameFull: Oleinik N – PersonEntity: Name: NameFull: Saatci O – PersonEntity: Name: NameFull: Darawshi O – PersonEntity: Name: NameFull: Das S – PersonEntity: Name: NameFull: Oberhoeltzer N – PersonEntity: Name: NameFull: Gautam A – PersonEntity: Name: NameFull: Mills S – PersonEntity: Name: NameFull: DeMass R – PersonEntity: Name: NameFull: Hedley Z – PersonEntity: Name: NameFull: Liu Y – PersonEntity: Name: NameFull: Parikh RY – PersonEntity: Name: NameFull: Paul S – PersonEntity: Name: NameFull: Seal S – PersonEntity: Name: NameFull: Smith CD – PersonEntity: Name: NameFull: Lilly MB – PersonEntity: Name: NameFull: Gangaraju VK – PersonEntity: Name: NameFull: Peterson Y – PersonEntity: Name: NameFull: Mehrotra M – PersonEntity: Name: NameFull: Hill E – PersonEntity: Name: NameFull: Sahin O – PersonEntity: Name: NameFull: Leitinger N – PersonEntity: Name: NameFull: Rodriguez PC – PersonEntity: Name: NameFull: Ogretmen B – PersonEntity: Name: NameFull: Mehrotra S IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 06 Text: 2026 Jun 02 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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