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Phosphoproteomic profiling reveals post-translational dysregulation in Huntington's disease patient-derived neurons.

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Title: Phosphoproteomic profiling reveals post-translational dysregulation in Huntington's disease patient-derived neurons.
Authors: Danics L; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary.; HUN-REN-SU Cerebrovascular and Neurocognitive Diseases Research Group, Budapest, Hungary., Muralidharan C; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary.; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, Sweden., Varga Á; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary.; HUN-REN-SZTAKI-SU Rejuvenation Research Group, HUN-REN Office for Supported Research Groups (TKI), Budapest, Hungary., Rezeli M; Division for Biomedical Engineering, Department of Biomedical Engineering, Lund University, Lund, Sweden.; BioMS-Swedish National Infrastructure for Biological Mass Spectrometry, Lund University, Lund, Sweden., Gil J; Clinical Chemistry, Department of Translational Medicine, Lund University, Lund, Sweden., Abbas AA; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary., Pap Á; Single Cell Omics Advanced Core Facility, Hungarian Centre of Excellence for Molecular Medicine, Szeged, Hungary.; Laboratory of Proteomics, Complex Molecular and Cell Biology Service Centre, HUN-REN Biological Research Centre, Szeged, Hungary., Park AS; Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada.; Centre de Recherche Sur Le Cerveau Et L'apprentissage (CIRCA), University of Montreal, Montreal, QC, Canada., Cserhalmi M; MTA-HUN-REN RCNS Lendület 'Momentum' DNA Repair Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary., Legault EM; Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada.; Centre de Recherche Sur Le Cerveau Et L'apprentissage (CIRCA), University of Montreal, Montreal, QC, Canada., Sőth Á; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary., Jamniczky D; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary., Zsoldos R; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary.; HUN-REN-SZTAKI-SU Rejuvenation Research Group, HUN-REN Office for Supported Research Groups (TKI), Budapest, Hungary., Barker RA; Cambridge Stem Cell Institute and John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge, UK., Róna G; MTA-HUN-REN RCNS Lendület 'Momentum' DNA Repair Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA., Drouin-Ouellet J; Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada.; Centre de Recherche Sur Le Cerveau Et L'apprentissage (CIRCA), University of Montreal, Montreal, QC, Canada., Markó-Varga G; BioMS-Swedish National Infrastructure for Biological Mass Spectrometry, Lund University, Lund, Sweden., Darula Z; Single Cell Omics Advanced Core Facility, Hungarian Centre of Excellence for Molecular Medicine, Szeged, Hungary.; Laboratory of Proteomics, Complex Molecular and Cell Biology Service Centre, HUN-REN Biological Research Centre, Szeged, Hungary., Pircs K; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary. pircs.karolina@semmelweis.hu.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary. pircs.karolina@semmelweis.hu.; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, Sweden. pircs.karolina@semmelweis.hu.; HUN-REN-SZTAKI-SU Rejuvenation Research Group, HUN-REN Office for Supported Research Groups (TKI), Budapest, Hungary. pircs.karolina@semmelweis.hu.
Source: Cellular & molecular biology letters [Cell Mol Biol Lett] 2026 Jun 02; Vol. 31 (1). Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9607427 Publication Model: Electronic Cited Medium: Internet ISSN: 1689-1392 (Electronic) Linking ISSN: 14258153 NLM ISO Abbreviation: Cell Mol Biol Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phosphoproteomic profiling reveals post-translational dysregulation in Huntington's disease patient-derived neurons.
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  Data: <searchLink fieldCode="AU" term="%22Danics+L%22">Danics L</searchLink>; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary.; HUN-REN-SU Cerebrovascular and Neurocognitive Diseases Research Group, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Muralidharan+C%22">Muralidharan C</searchLink>; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary.; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Varga+Á%22">Varga Á</searchLink>; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary.; HUN-REN-SZTAKI-SU Rejuvenation Research Group, HUN-REN Office for Supported Research Groups (TKI), Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Rezeli+M%22">Rezeli M</searchLink>; Division for Biomedical Engineering, Department of Biomedical Engineering, Lund University, Lund, Sweden.; BioMS-Swedish National Infrastructure for Biological Mass Spectrometry, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Gil+J%22">Gil J</searchLink>; Clinical Chemistry, Department of Translational Medicine, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Abbas+AA%22">Abbas AA</searchLink>; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Pap+Á%22">Pap Á</searchLink>; Single Cell Omics Advanced Core Facility, Hungarian Centre of Excellence for Molecular Medicine, Szeged, Hungary.; Laboratory of Proteomics, Complex Molecular and Cell Biology Service Centre, HUN-REN Biological Research Centre, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Park+AS%22">Park AS</searchLink>; Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada.; Centre de Recherche Sur Le Cerveau Et L'apprentissage (CIRCA), University of Montreal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Cserhalmi+M%22">Cserhalmi M</searchLink>; MTA-HUN-REN RCNS Lendület 'Momentum' DNA Repair Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Legault+EM%22">Legault EM</searchLink>; Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada.; Centre de Recherche Sur Le Cerveau Et L'apprentissage (CIRCA), University of Montreal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Sőth+Á%22">Sőth Á</searchLink>; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Jamniczky+D%22">Jamniczky D</searchLink>; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Zsoldos+R%22">Zsoldos R</searchLink>; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary.; HUN-REN-SZTAKI-SU Rejuvenation Research Group, HUN-REN Office for Supported Research Groups (TKI), Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Barker+RA%22">Barker RA</searchLink>; Cambridge Stem Cell Institute and John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Róna+G%22">Róna G</searchLink>; MTA-HUN-REN RCNS Lendület 'Momentum' DNA Repair Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Drouin-Ouellet+J%22">Drouin-Ouellet J</searchLink>; Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada.; Centre de Recherche Sur Le Cerveau Et L'apprentissage (CIRCA), University of Montreal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Markó-Varga+G%22">Markó-Varga G</searchLink>; BioMS-Swedish National Infrastructure for Biological Mass Spectrometry, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Darula+Z%22">Darula Z</searchLink>; Single Cell Omics Advanced Core Facility, Hungarian Centre of Excellence for Molecular Medicine, Szeged, Hungary.; Laboratory of Proteomics, Complex Molecular and Cell Biology Service Centre, HUN-REN Biological Research Centre, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Pircs+K%22">Pircs K</searchLink>; Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary. pircs.karolina@semmelweis.hu.; Hungarian Centre of Excellence for Molecular Medicine-Semmelweis University (HCEMM-SU), Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary. pircs.karolina@semmelweis.hu.; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, Sweden. pircs.karolina@semmelweis.hu.; HUN-REN-SZTAKI-SU Rejuvenation Research Group, HUN-REN Office for Supported Research Groups (TKI), Budapest, Hungary. pircs.karolina@semmelweis.hu.
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  Data: <searchLink fieldCode="JN" term="%229607427%22">Cellular & molecular biology letters</searchLink> [Cell Mol Biol Lett] 2026 Jun 02; Vol. 31 (1). <i>Date of Electronic Publication: </i>2026 Jun 02.
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