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Extracellular vesicles as biomarkers of disease progression and therapeutic response in patients with spinal muscular atrophy.

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Title: Extracellular vesicles as biomarkers of disease progression and therapeutic response in patients with spinal muscular atrophy.
Authors: Poulin KL; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., René CA; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Smith IC; NeuroMuscular Centre, The Ottawa Hospital, Ottawa, ON K1Y4E9, Canada., Vacratsis PO; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B3P4, Canada., Burger D; Inflammation and Chronic Disease Program, Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; School of Pharmaceutical Sciences, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., McMillan HJ; Department of Pediatrics, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON K1H 8L1, Canada., Kothary R; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, ON K1H 8L6, Canada., Perkins TJ; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Warman-Chardon J; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; NeuroMuscular Centre, The Ottawa Hospital, Ottawa, ON K1Y4E9, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, ON K1H 8L6, Canada.; Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada., Parks RJ; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, ON K1H 8L6, Canada.
Source: Molecular therapy. Advances [Mol Ther Adv] 2026 May 13; Vol. 34 (2), pp. 201757. Date of Electronic Publication: 2026 May 13 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Country of Publication: United States NLM ID: 9919257804006676 Publication Model: eCollection Cited Medium: Internet ISSN: 3117-387X (Electronic) Linking ISSN: 3117387X NLM ISO Abbreviation: Mol Ther Adv Subsets: PubMed not MEDLINE
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  Data: Extracellular vesicles as biomarkers of disease progression and therapeutic response in patients with spinal muscular atrophy.
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  Data: <searchLink fieldCode="AU" term="%22Poulin+KL%22">Poulin KL</searchLink>; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22René+CA%22">René CA</searchLink>; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1H 8M5, Canada.<br /><searchLink fieldCode="AU" term="%22Smith+IC%22">Smith IC</searchLink>; NeuroMuscular Centre, The Ottawa Hospital, Ottawa, ON K1Y4E9, Canada.<br /><searchLink fieldCode="AU" term="%22Vacratsis+PO%22">Vacratsis PO</searchLink>; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B3P4, Canada.<br /><searchLink fieldCode="AU" term="%22Burger+D%22">Burger D</searchLink>; Inflammation and Chronic Disease Program, Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; School of Pharmaceutical Sciences, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.<br /><searchLink fieldCode="AU" term="%22McMillan+HJ%22">McMillan HJ</searchLink>; Department of Pediatrics, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON K1H 8L1, Canada.<br /><searchLink fieldCode="AU" term="%22Kothary+R%22">Kothary R</searchLink>; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, ON K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22Perkins+TJ%22">Perkins TJ</searchLink>; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1H 8M5, Canada.<br /><searchLink fieldCode="AU" term="%22Warman-Chardon+J%22">Warman-Chardon J</searchLink>; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; NeuroMuscular Centre, The Ottawa Hospital, Ottawa, ON K1Y4E9, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, ON K1H 8L6, Canada.; Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada.<br /><searchLink fieldCode="AU" term="%22Parks+RJ%22">Parks RJ</searchLink>; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, ON K1H 8L6, Canada.
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  Data: <searchLink fieldCode="JN" term="%229919257804006676%22">Molecular therapy. Advances</searchLink> [Mol Ther Adv] 2026 May 13; Vol. 34 (2), pp. 201757. <i>Date of Electronic Publication: </i>2026 May 13 (<i>Print Publication: </i>2026).
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