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DHODH Inhibitors Based on the Vidofludimus Scaffold Containing Carboxylic Acid Bioisosteres Exert a Superior Broad-Spectrum Antiviral Activity.

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Title: DHODH Inhibitors Based on the Vidofludimus Scaffold Containing Carboxylic Acid Bioisosteres Exert a Superior Broad-Spectrum Antiviral Activity.
Authors: Herrmann A; Immunic AG, 82166 Gräfelfing, Germany.; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Hahn F; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.; Institute of Virology, Ulm University Hospital, 89081 Ulm, Germany., Wangen C; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Wagner S; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Cordsmeier A; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Irrgang P; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Weil T; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Hunszinger V; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Groß R; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Heinen N; Department of Molecular and Medical Virology, Ruhr-University Bochum, 44801 Bochum, Germany., Pfaender S; Institute of Virology and Cell Biology, University of Luebeck, 23562 Lübeck, Germany.; Leibniz Institute of Virology, 20251 Hamburg, Germany., Westhoven S; Leibniz Institute of Virology, 20251 Hamburg, Germany., Reuter S; Department of Pulmonary Medicine, University Medical Center Essen - Ruhrlandklinik, 45239 Essen, Germany.; Mainz Lung Center, Pneumology Department, University Medical Center and Marienhaus Clinic, 55131 Mainz, Germany., Schedel M; Department of Pulmonary Medicine, University Medical Center Essen - Ruhrlandklinik, 45239 Essen, Germany.; Department of Pulmonary Medicine, University Medical Center Essen, 45239 Essen, Germany., Uhlig N; Fraunhofer-Institute for Cell Therapy and Immunology (IZI), Department of Infection Research and Diagnostics, Unit Preclinical Validation, 04103 Leipzig, Germany., Eberlein V; Fraunhofer-Institute for Cell Therapy and Immunology (IZI), Department of Infection Research and Diagnostics, Unit Preclinical Validation, 04103 Leipzig, Germany., Issmail L; Fraunhofer-Institute for Cell Therapy and Immunology (IZI), Department of Infection Research and Diagnostics, Unit Preclinical Validation, 04103 Leipzig, Germany., Grunwald T; Fraunhofer-Institute for Cell Therapy and Immunology (IZI), Department of Infection Research and Diagnostics, Unit Preclinical Validation, 04103 Leipzig, Germany., Klopfleisch R; Institute of Veterinary Pathology, Freie Universität Berlin, 14163 Berlin, Germany., Ensser A; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Tenbusch M; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Münch J; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Sparrer KMJ; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.; Neurovirology and Neuroinflammation, German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany., Marschall M; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Kohlhof H; Immunic AG, 82166 Gräfelfing, Germany., Vitt D; Immunic AG, 82166 Gräfelfing, Germany., Gege C; Immunic AG, 82166 Gräfelfing, Germany.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Jun 25; Vol. 69 (12), pp. 14255-14274. Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: DHODH Inhibitors Based on the Vidofludimus Scaffold Containing Carboxylic Acid Bioisosteres Exert a Superior Broad-Spectrum Antiviral Activity.
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  Data: <searchLink fieldCode="AU" term="%22Herrmann+A%22">Herrmann A</searchLink>; Immunic AG, 82166 Gräfelfing, Germany.; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Hahn+F%22">Hahn F</searchLink>; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.; Institute of Virology, Ulm University Hospital, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Wangen+C%22">Wangen C</searchLink>; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+S%22">Wagner S</searchLink>; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Cordsmeier+A%22">Cordsmeier A</searchLink>; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Irrgang+P%22">Irrgang P</searchLink>; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Weil+T%22">Weil T</searchLink>; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Hunszinger+V%22">Hunszinger V</searchLink>; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Groß+R%22">Groß R</searchLink>; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Heinen+N%22">Heinen N</searchLink>; Department of Molecular and Medical Virology, Ruhr-University Bochum, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Pfaender+S%22">Pfaender S</searchLink>; Institute of Virology and Cell Biology, University of Luebeck, 23562 Lübeck, Germany.; Leibniz Institute of Virology, 20251 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Westhoven+S%22">Westhoven S</searchLink>; Leibniz Institute of Virology, 20251 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Reuter+S%22">Reuter S</searchLink>; Department of Pulmonary Medicine, University Medical Center Essen - Ruhrlandklinik, 45239 Essen, Germany.; Mainz Lung Center, Pneumology Department, University Medical Center and Marienhaus Clinic, 55131 Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Schedel+M%22">Schedel M</searchLink>; Department of Pulmonary Medicine, University Medical Center Essen - Ruhrlandklinik, 45239 Essen, Germany.; Department of Pulmonary Medicine, University Medical Center Essen, 45239 Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Uhlig+N%22">Uhlig N</searchLink>; Fraunhofer-Institute for Cell Therapy and Immunology (IZI), Department of Infection Research and Diagnostics, Unit Preclinical Validation, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Eberlein+V%22">Eberlein V</searchLink>; Fraunhofer-Institute for Cell Therapy and Immunology (IZI), Department of Infection Research and Diagnostics, Unit Preclinical Validation, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Issmail+L%22">Issmail L</searchLink>; Fraunhofer-Institute for Cell Therapy and Immunology (IZI), Department of Infection Research and Diagnostics, Unit Preclinical Validation, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Grunwald+T%22">Grunwald T</searchLink>; Fraunhofer-Institute for Cell Therapy and Immunology (IZI), Department of Infection Research and Diagnostics, Unit Preclinical Validation, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Klopfleisch+R%22">Klopfleisch R</searchLink>; Institute of Veterinary Pathology, Freie Universität Berlin, 14163 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ensser+A%22">Ensser A</searchLink>; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Tenbusch+M%22">Tenbusch M</searchLink>; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Münch+J%22">Münch J</searchLink>; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Sparrer+KMJ%22">Sparrer KMJ</searchLink>; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.; Neurovirology and Neuroinflammation, German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Marschall+M%22">Marschall M</searchLink>; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Kohlhof+H%22">Kohlhof H</searchLink>; Immunic AG, 82166 Gräfelfing, Germany.<br /><searchLink fieldCode="AU" term="%22Vitt+D%22">Vitt D</searchLink>; Immunic AG, 82166 Gräfelfing, Germany.<br /><searchLink fieldCode="AU" term="%22Gege+C%22">Gege C</searchLink>; Immunic AG, 82166 Gräfelfing, Germany.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Jun 25; Vol. 69 (12), pp. 14255-14274. <i>Date of Electronic Publication: </i>2026 Jun 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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