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Fingolimod increases cellular resistance to HIV-1 infection and limits viral reservoir size in peripheral CD4+ T-cells.

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Title: Fingolimod increases cellular resistance to HIV-1 infection and limits viral reservoir size in peripheral CD4+ T-cells.
Authors: Moraga E; AIDS and HIV Infection Group, Fundació de Recerca Clínic Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.; Department of Medicine, Universitat de Barcelona (UB), Barcelona, Spain., Climent N; AIDS and HIV Infection Group, Fundació de Recerca Clínic Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.; Department of Medicine, Universitat de Barcelona (UB), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Infecciosas CIBER (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Sánchez-Molina A; AIDS and HIV Infection Group, Fundació de Recerca Clínic Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.; Department of Medicine, Universitat de Barcelona (UB), Barcelona, Spain., Vicens-Artés S; AIDS and HIV Infection Group, Fundació de Recerca Clínic Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain., Maleno MJ; AIDS and HIV Infection Group, Fundació de Recerca Clínic Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain., Valero López G; Neurology Department, Hospital Clínico Universitario Virgen de la Arrixaca/IMIB, CSUR Multiple Sclerosis and Clinical Neuroimmunology Unit, Murcia, Spain., Galera Peñaranda C; Hospital Clínico Universitario Virgen de la Arrixaca/ IMIB, HIV Unit, Murcia, Spain., Ambrosioni J; AIDS and HIV Infection Group, Fundació de Recerca Clínic Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.; Department of Medicine, Universitat de Barcelona (UB), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Infecciosas CIBER (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; Infectious Diseases Service, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain., Miró JM; AIDS and HIV Infection Group, Fundació de Recerca Clínic Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.; Department of Medicine, Universitat de Barcelona (UB), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Infecciosas CIBER (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; Infectious Diseases Service, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.; Reial Academia de Medicina de Catalunya (RAMC), Barcelona, Spain., Mallolas J; AIDS and HIV Infection Group, Fundació de Recerca Clínic Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.; Department of Medicine, Universitat de Barcelona (UB), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Infecciosas CIBER (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; Infectious Diseases Service, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain., Albendín-Iglesias H; Hospital Clínico Universitario Virgen de la Arrixaca/ IMIB, HIV Unit, Murcia, Spain., Alcamí J; AIDS and HIV Infection Group, Fundació de Recerca Clínic Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.; Department of Medicine, Universitat de Barcelona (UB), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Infecciosas CIBER (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Sánchez-Palomino S; AIDS and HIV Infection Group, Fundació de Recerca Clínic Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.; Department of Medicine, Universitat de Barcelona (UB), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Infecciosas CIBER (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Source: PLoS pathogens [PLoS Pathog] 2026 Jun 03; Vol. 22 (6), pp. e1014266. Date of Electronic Publication: 2026 Jun 03 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fingolimod increases cellular resistance to HIV-1 infection and limits viral reservoir size in peripheral CD4+ T-cells.
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