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Optimizing microhomology-based genome editing by engineering DNA polymerase θ for improved efficiency and reduced on-target indels.

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Title: Optimizing microhomology-based genome editing by engineering DNA polymerase θ for improved efficiency and reduced on-target indels.
Authors: Wang W; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Zhou M; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Department of Cell Biology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Ji T; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Jiang Q; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Zhao J; The First School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Xu Z; The Second School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Liu R; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Luo Y; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Han F; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Cong L; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94306, USA., Fan L; Department of Hematology, Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, China. Electronic address: fanlei@jsph.org.cn., Chen C; Department of Pathology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address: chenchen@njmu.edu.cn., Wang C; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address: wangchengkun@njmu.edu.cn.
Source: Cell reports methods [Cell Rep Methods] 2026 Jun 03, pp. 101474. Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918227360606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-2375 (Electronic) Linking ISSN: 26672375 NLM ISO Abbreviation: Cell Rep Methods Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Optimizing microhomology-based genome editing by engineering DNA polymerase θ for improved efficiency and reduced on-target indels.
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  Data: <searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, Jiangsu 211166, China.<br /><searchLink fieldCode="AU" term="%22Zhou+M%22">Zhou M</searchLink>; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Department of Cell Biology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.<br /><searchLink fieldCode="AU" term="%22Ji+T%22">Ji T</searchLink>; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.<br /><searchLink fieldCode="AU" term="%22Jiang+Q%22">Jiang Q</searchLink>; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; The First School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; The Second School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China.<br /><searchLink fieldCode="AU" term="%22Liu+R%22">Liu R</searchLink>; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.<br /><searchLink fieldCode="AU" term="%22Luo+Y%22">Luo Y</searchLink>; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.<br /><searchLink fieldCode="AU" term="%22Han+F%22">Han F</searchLink>; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China.<br /><searchLink fieldCode="AU" term="%22Cong+L%22">Cong L</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94306, USA.<br /><searchLink fieldCode="AU" term="%22Fan+L%22">Fan L</searchLink>; Department of Hematology, Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, China. Electronic address: fanlei@jsph.org.cn.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of Pathology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address: chenchen@njmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address: wangchengkun@njmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229918227360606676%22">Cell reports methods</searchLink> [Cell Rep Methods] 2026 Jun 03, pp. 101474. <i>Date of Electronic Publication: </i>2026 Jun 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%22">Elsevier Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9918227360606676 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2667-2375 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226672375%22">26672375 </searchLink><i>NLM ISO Abbreviation: </i>Cell Rep Methods <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun 03
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