Optimizing microhomology-based genome editing by engineering DNA polymerase θ for improved efficiency and reduced on-target indels.
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| Title: | Optimizing microhomology-based genome editing by engineering DNA polymerase θ for improved efficiency and reduced on-target indels. |
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| Authors: | Wang W; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Zhou M; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Department of Cell Biology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Ji T; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Jiang Q; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Zhao J; The First School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Xu Z; The Second School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Liu R; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Luo Y; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Han F; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Cong L; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94306, USA., Fan L; Department of Hematology, Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, China. Electronic address: fanlei@jsph.org.cn., Chen C; Department of Pathology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address: chenchen@njmu.edu.cn., Wang C; Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address: wangchengkun@njmu.edu.cn. |
| Source: | Cell reports methods [Cell Rep Methods] 2026 Jun 03, pp. 101474. Date of Electronic Publication: 2026 Jun 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918227360606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-2375 (Electronic) Linking ISSN: 26672375 NLM ISO Abbreviation: Cell Rep Methods Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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