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MRI end-points for clinical trials in ataxias: recommendations from the Ataxia Global Initiative MRI Biomarkers Working Group.

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Title: MRI end-points for clinical trials in ataxias: recommendations from the Ataxia Global Initiative MRI Biomarkers Working Group.
Authors: Öz G; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA. gulin@cmrr.umn.edu., Cocozza S; Department of Advanced Biomedical Sciences, University of Naples 'Federico II', Naples, Italy., Rezende TJR; Department of Neurology, School of Medical Sciences, University of Campinas, Campinas, Brazil., Henry PG; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA., Faber J; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Center for Neurology, Department of Parkinson's Disease, Sleep and Movement Disorders, University Hospital Bonn, Bonn, Germany.; Department of Neuroradiology, University Hospital Bonn, Bonn, Germany., Harding IH; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Corporate Authors: Ataxia Global Initiative Working Group on MRI Biomarkers
Source: Nature reviews. Neurology [Nat Rev Neurol] 2026 Jul; Vol. 22 (7), pp. 439-456. Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article; Review; Consensus Statement
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500072 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-4766 (Electronic) Linking ISSN: 17594758 NLM ISO Abbreviation: Nat Rev Neurol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Öz+G%22">Öz G</searchLink>; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA. gulin@cmrr.umn.edu.<br /><searchLink fieldCode="AU" term="%22Cocozza+S%22">Cocozza S</searchLink>; Department of Advanced Biomedical Sciences, University of Naples 'Federico II', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Rezende+TJR%22">Rezende TJR</searchLink>; Department of Neurology, School of Medical Sciences, University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Henry+PG%22">Henry PG</searchLink>; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Faber+J%22">Faber J</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Center for Neurology, Department of Parkinson's Disease, Sleep and Movement Disorders, University Hospital Bonn, Bonn, Germany.; Department of Neuroradiology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Harding+IH%22">Harding IH</searchLink>; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
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  Data: <searchLink fieldCode="CA" term="%22Ataxia+Global+Initiative+Working+Group+on+MRI+Biomarkers%22">Ataxia Global Initiative Working Group on MRI Biomarkers</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101500072%22">Nature reviews. Neurology</searchLink> [Nat Rev Neurol] 2026 Jul; Vol. 22 (7), pp. 439-456. <i>Date of Electronic Publication: </i>2026 Jun 03.
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        Value: 10.1038/s41582-026-01218-7
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      – TitleFull: MRI end-points for clinical trials in ataxias: recommendations from the Ataxia Global Initiative MRI Biomarkers Working Group.
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              Text: 2026 Jul
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