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Direct Mapping of CDK2 Substrates in Embryonic Stem Cells Uncovers an AP-Site Repair Mechanism via HMCES Phosphorylation.

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Title: Direct Mapping of CDK2 Substrates in Embryonic Stem Cells Uncovers an AP-Site Repair Mechanism via HMCES Phosphorylation.
Authors: Topacio BR; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA.; Institute for The Biology of Stem Cells, University of California, Santa Cruz, CA, USA.; Genomics Institute, University of California, Santa Cruz, CA, USA.; National Cancer Institute, Laboratory of Biochemistry and Molecular Biology, National Institutes of Health, Bethesda, USA.; Equal contribution., Esvald EE; National Cancer Institute, Laboratory of Biochemistry and Molecular Biology, National Institutes of Health, Bethesda, USA.; Equal contribution., Tuvikene J; National Cancer Institute, Laboratory of Biochemistry and Molecular Biology, National Institutes of Health, Bethesda, USA., Langroudi L; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA.; Institute for The Biology of Stem Cells, University of California, Santa Cruz, CA, USA.; Genomics Institute, University of California, Santa Cruz, CA, USA., Maity TK; National Cancer Institute, Laboratory of Cell Biology, National Institutes of Health, Bethesda, MD, USA., Jenkins LM; National Cancer Institute, Laboratory of Cell Biology, National Institutes of Health, Bethesda, MD, USA., Stracker TH; National Cancer Institute, Radiation Oncology Branch, National Institutes of Health, Bethesda, MD, USA., Kõivomägi M; National Cancer Institute, Laboratory of Biochemistry and Molecular Biology, National Institutes of Health, Bethesda, USA., Shariati SA; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA.; Institute for The Biology of Stem Cells, University of California, Santa Cruz, CA, USA.; Genomics Institute, University of California, Santa Cruz, CA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 20. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Direct Mapping of CDK2 Substrates in Embryonic Stem Cells Uncovers an AP-Site Repair Mechanism via HMCES Phosphorylation.
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  Data: <searchLink fieldCode="AU" term="%22Topacio+BR%22">Topacio BR</searchLink>; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA.; Institute for The Biology of Stem Cells, University of California, Santa Cruz, CA, USA.; Genomics Institute, University of California, Santa Cruz, CA, USA.; National Cancer Institute, Laboratory of Biochemistry and Molecular Biology, National Institutes of Health, Bethesda, USA.; Equal contribution.<br /><searchLink fieldCode="AU" term="%22Esvald+EE%22">Esvald EE</searchLink>; National Cancer Institute, Laboratory of Biochemistry and Molecular Biology, National Institutes of Health, Bethesda, USA.; Equal contribution.<br /><searchLink fieldCode="AU" term="%22Tuvikene+J%22">Tuvikene J</searchLink>; National Cancer Institute, Laboratory of Biochemistry and Molecular Biology, National Institutes of Health, Bethesda, USA.<br /><searchLink fieldCode="AU" term="%22Langroudi+L%22">Langroudi L</searchLink>; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA.; Institute for The Biology of Stem Cells, University of California, Santa Cruz, CA, USA.; Genomics Institute, University of California, Santa Cruz, CA, USA.<br /><searchLink fieldCode="AU" term="%22Maity+TK%22">Maity TK</searchLink>; National Cancer Institute, Laboratory of Cell Biology, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Jenkins+LM%22">Jenkins LM</searchLink>; National Cancer Institute, Laboratory of Cell Biology, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Stracker+TH%22">Stracker TH</searchLink>; National Cancer Institute, Radiation Oncology Branch, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kõivomägi+M%22">Kõivomägi M</searchLink>; National Cancer Institute, Laboratory of Biochemistry and Molecular Biology, National Institutes of Health, Bethesda, USA.<br /><searchLink fieldCode="AU" term="%22Shariati+SA%22">Shariati SA</searchLink>; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA.; Institute for The Biology of Stem Cells, University of California, Santa Cruz, CA, USA.; Genomics Institute, University of California, Santa Cruz, CA, USA.
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        Value: 10.64898/2026.05.18.726044
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