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Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning.

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Title: Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning.
Authors: Patterson C; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Chattopadhyay T; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Saykin AJ; Indiana Alzheimer's Disease Research Center and Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA., Davatzikos C; Artificial Intelligence in Biomedical Imaging Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA., Mormino EC; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Cogen Facility, Stanford, CA, USA., Tosun D; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA., Beecham GW; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Biber SA; National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA., Kukull WA; Department of Neurology, Washington University, St Louis, USA., Risacher SL; Gerontology and Geriatrics, Internal Medicine (Winston-Salem), Wake Forest University School of Medicine, Winston-Salem, NC, USA., Montine TJ; Department of Pathology, Stanford University School of Medicine,Stanford, CA, USA., Johnson SC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Health Sciences Learning Center, Madison, WI, USA., Shen L; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Huang H; Department of Computer Science, University of Maryland, College Park, MD, USA., Erus G; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA., Jun GR; Biomedical Genetics Section, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.; Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.; Bioinformatics Program, Boston University, Boston, Massachusetts, USA., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Crane PK; The John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Cuccaro ML; The John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA., Archer DB; Department of Neurology, Vanderbilt Health, Nashville, TN, USA., Landman BA; Electrical and Computer Engineer, Vanderbilt University, Nashville, TN 37235, USA., Toga AW; Laboratory of Neuroimaging, Stevens Institute of Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA., Hohman TJ; Department of Neurology, Vanderbilt Health, Nashville, TN, USA., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 23. Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning.
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  Data: <searchLink fieldCode="AU" term="%22Patterson+C%22">Patterson C</searchLink>; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chattopadhyay+T%22">Chattopadhyay T</searchLink>; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.<br /><searchLink fieldCode="AU" term="%22Thomopoulos+SI%22">Thomopoulos SI</searchLink>; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.<br /><searchLink fieldCode="AU" term="%22Saykin+AJ%22">Saykin AJ</searchLink>; Indiana Alzheimer's Disease Research Center and Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Davatzikos+C%22">Davatzikos C</searchLink>; Artificial Intelligence in Biomedical Imaging Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.<br /><searchLink fieldCode="AU" term="%22Mormino+EC%22">Mormino EC</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Cogen Facility, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tosun+D%22">Tosun D</searchLink>; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Beecham+GW%22">Beecham GW</searchLink>; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA.<br /><searchLink fieldCode="AU" term="%22Biber+SA%22">Biber SA</searchLink>; National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Kukull+WA%22">Kukull WA</searchLink>; Department of Neurology, Washington University, St Louis, USA.<br /><searchLink fieldCode="AU" term="%22Risacher+SL%22">Risacher SL</searchLink>; Gerontology and Geriatrics, Internal Medicine (Winston-Salem), Wake Forest University School of Medicine, Winston-Salem, NC, USA.<br /><searchLink fieldCode="AU" term="%22Montine+TJ%22">Montine TJ</searchLink>; Department of Pathology, Stanford University School of Medicine,Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+SC%22">Johnson SC</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Health Sciences Learning Center, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Shen+L%22">Shen L</searchLink>; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Department of Computer Science, University of Maryland, College Park, MD, USA.<br /><searchLink fieldCode="AU" term="%22Erus+G%22">Erus G</searchLink>; AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Jun+GR%22">Jun GR</searchLink>; Biomedical Genetics Section, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.; Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.; Bioinformatics Program, Boston University, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Mukherjee+S%22">Mukherjee S</searchLink>; Department of Medicine, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Crane+PK%22">Crane PK</searchLink>; The John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Cuccaro+ML%22">Cuccaro ML</searchLink>; The John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Archer+DB%22">Archer DB</searchLink>; Department of Neurology, Vanderbilt Health, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Landman+BA%22">Landman BA</searchLink>; Electrical and Computer Engineer, Vanderbilt University, Nashville, TN 37235, USA.<br /><searchLink fieldCode="AU" term="%22Toga+AW%22">Toga AW</searchLink>; Laboratory of Neuroimaging, Stevens Institute of Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.<br /><searchLink fieldCode="AU" term="%22Hohman+TJ%22">Hohman TJ</searchLink>; Department of Neurology, Vanderbilt Health, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+PM%22">Thompson PM</searchLink>; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
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