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Subcortical recruitment dissociates isoflurane emergence from distinct wakeful states in mice.

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Title: Subcortical recruitment dissociates isoflurane emergence from distinct wakeful states in mice.
Authors: Neiswanger C; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A., MacMillen LK; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A., Murry AD; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A., Szelenyi ER; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A., Navarrete J; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A.; Graduate Program in Neuroscience, University of Washington, Seattle, WA, U.S.A., Nota M; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A., Lazaro H; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Graduate Program in Neuroscience, University of Washington, Seattle, WA, U.S.A., Shin CC; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Undergraduate Neuroscience Program, University of Washington, Seattle, WA, U.S.A., Zhang J; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Undergraduate Biochemistry Program, University of Washington, Seattle, WA, U.S.A., Apley EA; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Undergraduate Biology Program, University of Washington, Seattle, WA, U.S.A., Zhang Y; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A.; Graduate Program in Neuroscience, University of Washington, Seattle, WA, U.S.A., Diaz C; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A., Schneider KN; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A., Goodwin NL; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A., Jin M; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY, U.S.A., Nilsson S; Platea Biosciences Inc, Seattle, WA., Ishii KK; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A., Stuber GD; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Department of Pharmacology, University of Washington, Seattle, WA, U.S.A., Bruchas MR; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Department of Pharmacology, University of Washington, Seattle, WA, U.S.A., Golden SA; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A., Heshmati M; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Subcortical recruitment dissociates isoflurane emergence from distinct wakeful states in mice.
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  Data: <searchLink fieldCode="AU" term="%22Neiswanger+C%22">Neiswanger C</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22MacMillen+LK%22">MacMillen LK</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Murry+AD%22">Murry AD</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Szelenyi+ER%22">Szelenyi ER</searchLink>; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Navarrete+J%22">Navarrete J</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A.; Graduate Program in Neuroscience, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Nota+M%22">Nota M</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Lazaro+H%22">Lazaro H</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Graduate Program in Neuroscience, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Shin+CC%22">Shin CC</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Undergraduate Neuroscience Program, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Undergraduate Biochemistry Program, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Apley+EA%22">Apley EA</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Undergraduate Biology Program, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A.; Graduate Program in Neuroscience, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Diaz+C%22">Diaz C</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Schneider+KN%22">Schneider KN</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Goodwin+NL%22">Goodwin NL</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Jin+M%22">Jin M</searchLink>; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY, U.S.A.<br /><searchLink fieldCode="AU" term="%22Nilsson+S%22">Nilsson S</searchLink>; Platea Biosciences Inc, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Ishii+KK%22">Ishii KK</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Stuber+GD%22">Stuber GD</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Department of Pharmacology, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Bruchas+MR%22">Bruchas MR</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Department of Pharmacology, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Golden+SA%22">Golden SA</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Heshmati+M%22">Heshmati M</searchLink>; Center for Excellence in Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, U.S.A.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, U.S.A.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, U.S.A.
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