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Transmembrane Domain Dominance Drives Emergent Signaling and Allosteric Inversion in mGlu1/5 Heterodimers.

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Title: Transmembrane Domain Dominance Drives Emergent Signaling and Allosteric Inversion in mGlu1/5 Heterodimers.
Authors: Steinfeld JB; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY, USA.; Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, NY, USA., Lei X; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Warren Center for Neuroscience Drug Discovery and Vanderbilt Institute for Translational Advances, Vanderbilt University, Nashville, TN, USA., Laramee M; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY, USA., Lin X; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY, USA., Rodriguez AL; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Warren Center for Neuroscience Drug Discovery and Vanderbilt Institute for Translational Advances, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA., Spearing PK; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Warren Center for Neuroscience Drug Discovery and Vanderbilt Institute for Translational Advances, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA., Asher WB; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY, USA., Niswender CM; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Warren Center for Neuroscience Drug Discovery and Vanderbilt Institute for Translational Advances, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA., Javitch JA; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY, USA.; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 22. Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Transmembrane Domain Dominance Drives Emergent Signaling and Allosteric Inversion in mGlu<subscript>1/5</subscript> Heterodimers.
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  Data: <searchLink fieldCode="AU" term="%22Steinfeld+JB%22">Steinfeld JB</searchLink>; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY, USA.; Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lei+X%22">Lei X</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Warren Center for Neuroscience Drug Discovery and Vanderbilt Institute for Translational Advances, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Laramee+M%22">Laramee M</searchLink>; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lin+X%22">Lin X</searchLink>; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+AL%22">Rodriguez AL</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Warren Center for Neuroscience Drug Discovery and Vanderbilt Institute for Translational Advances, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Spearing+PK%22">Spearing PK</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Warren Center for Neuroscience Drug Discovery and Vanderbilt Institute for Translational Advances, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Asher+WB%22">Asher WB</searchLink>; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Niswender+CM%22">Niswender CM</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Warren Center for Neuroscience Drug Discovery and Vanderbilt Institute for Translational Advances, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Javitch+JA%22">Javitch JA</searchLink>; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY, USA.; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
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              Text: 2026 May 22
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