Integration of single-cell and bulk RNA sequencing reveals divergent T-cell immune circuits and a shared osteo-immune pathway in spinal tuberculosis and brucellar spondylitis.
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| Title: | Integration of single-cell and bulk RNA sequencing reveals divergent T-cell immune circuits and a shared osteo-immune pathway in spinal tuberculosis and brucellar spondylitis. |
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| Authors: | Yang Z; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Research Centre for Prevention and Control of Bone and Joint Tuberculosis, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Yue X; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Liu Q; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Gu Z; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Ma L; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Tao Z; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Wang K; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Wei D; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Huang R; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Hu J; Research Centre for Prevention and Control of Bone and Joint Tuberculosis, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Niu N; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Research Centre for Prevention and Control of Bone and Joint Tuberculosis, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Shi J; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Research Centre for Prevention and Control of Bone and Joint Tuberculosis, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China. |
| Source: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2026 May 19; Vol. 16, pp. 1811708. Date of Electronic Publication: 2026 May 19 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2235-2988 |
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| DOI: | 10.3389/fcimb.2026.1811708 |
