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Integration of single-cell and bulk RNA sequencing reveals divergent T-cell immune circuits and a shared osteo-immune pathway in spinal tuberculosis and brucellar spondylitis.

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Title: Integration of single-cell and bulk RNA sequencing reveals divergent T-cell immune circuits and a shared osteo-immune pathway in spinal tuberculosis and brucellar spondylitis.
Authors: Yang Z; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Research Centre for Prevention and Control of Bone and Joint Tuberculosis, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Yue X; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Liu Q; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Gu Z; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Ma L; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Tao Z; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Wang K; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Wei D; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Huang R; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Hu J; Research Centre for Prevention and Control of Bone and Joint Tuberculosis, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Niu N; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Research Centre for Prevention and Control of Bone and Joint Tuberculosis, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China., Shi J; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Research Centre for Prevention and Control of Bone and Joint Tuberculosis, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Source: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2026 May 19; Vol. 16, pp. 1811708. Date of Electronic Publication: 2026 May 19 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integration of single-cell and bulk RNA sequencing reveals divergent T-cell immune circuits and a shared osteo-immune pathway in spinal tuberculosis and brucellar spondylitis.
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  Data: <searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Research Centre for Prevention and Control of Bone and Joint Tuberculosis, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.<br /><searchLink fieldCode="AU" term="%22Yue+X%22">Yue X</searchLink>; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.<br /><searchLink fieldCode="AU" term="%22Gu+Z%22">Gu Z</searchLink>; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.<br /><searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink>; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.<br /><searchLink fieldCode="AU" term="%22Tao+Z%22">Tao Z</searchLink>; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.<br /><searchLink fieldCode="AU" term="%22Wang+K%22">Wang K</searchLink>; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.<br /><searchLink fieldCode="AU" term="%22Wei+D%22">Wei D</searchLink>; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.<br /><searchLink fieldCode="AU" term="%22Huang+R%22">Huang R</searchLink>; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Research Centre for Prevention and Control of Bone and Joint Tuberculosis, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.<br /><searchLink fieldCode="AU" term="%22Niu+N%22">Niu N</searchLink>; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Research Centre for Prevention and Control of Bone and Joint Tuberculosis, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.<br /><searchLink fieldCode="AU" term="%22Shi+J%22">Shi J</searchLink>; Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.; Research Centre for Prevention and Control of Bone and Joint Tuberculosis, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
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  Data: <searchLink fieldCode="JN" term="%22101585359%22">Frontiers in cellular and infection microbiology</searchLink> [Front Cell Infect Microbiol] 2026 May 19; Vol. 16, pp. 1811708. <i>Date of Electronic Publication: </i>2026 May 19 (<i>Print Publication: </i>2026).
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        Value: 10.3389/fcimb.2026.1811708
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        Text: English
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      – TitleFull: Integration of single-cell and bulk RNA sequencing reveals divergent T-cell immune circuits and a shared osteo-immune pathway in spinal tuberculosis and brucellar spondylitis.
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              Text: 2026 May 19
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