Design, synthesis and evaluation of an uncharged broad spectrum quinoline-oxime hybrid for the reactivation of nerve agent-inhibited human acetylcholinesterase.
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| Title: | Design, synthesis and evaluation of an uncharged broad spectrum quinoline-oxime hybrid for the reactivation of nerve agent-inhibited human acetylcholinesterase. |
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| Authors: | De Sousa J; École de Chimie Polymère et Matériaux ECPM, Université de Strasbourg, ICPEES UMR CNRS 7515, Strasbourg, F-67087, France., Calas AG; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France., De La Mora E; Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, Grenoble, F-38000, France., Landry C; Université d'Artois (UArtois), UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Lens, F-62307, France., Hanak AS; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France., Maryan-Instone A; School of Chemistry and Chemical Engineering, University of Southampton, Highfield, Southampton, SO17 1BJ, UK., Gastellier AJ; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France., Coisne C; Université d'Artois (UArtois), UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Lens, F-62307, France., Courageux C; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France., Hachani J; Université d'Artois (UArtois), UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Lens, F-62307, France., Gosselet F; Université d'Artois (UArtois), UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Lens, F-62307, France., Dehouck MP; Université d'Artois (UArtois), UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Lens, F-62307, France., Rousseau C; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France., Timperley CM; Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK., Weik M; Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, Grenoble, F-38000, France., Nachon F; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France., Brown RCD; School of Chemistry and Chemical Engineering, University of Southampton, Highfield, Southampton, SO17 1BJ, UK., Baati R; École de Chimie Polymère et Matériaux ECPM, Université de Strasbourg, ICPEES UMR CNRS 7515, Strasbourg, F-67087, France., Dias J; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France. Electronic address: jose.d@iasdef.gouv.fr. |
| Source: | European journal of medicinal chemistry [Eur J Med Chem] 2026 Oct 15; Vol. 316, pp. 119023. Date of Electronic Publication: 2026 Jun 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42241775 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Design, synthesis and evaluation of an uncharged broad spectrum quinoline-oxime hybrid for the reactivation of nerve agent-inhibited human acetylcholinesterase. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22De+Sousa+J%22">De Sousa J</searchLink>; École de Chimie Polymère et Matériaux ECPM, Université de Strasbourg, ICPEES UMR CNRS 7515, Strasbourg, F-67087, France.<br /><searchLink fieldCode="AU" term="%22Calas+AG%22">Calas AG</searchLink>; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France.<br /><searchLink fieldCode="AU" term="%22De+La+Mora+E%22">De La Mora E</searchLink>; Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, Grenoble, F-38000, France.<br /><searchLink fieldCode="AU" term="%22Landry+C%22">Landry C</searchLink>; Université d'Artois (UArtois), UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Lens, F-62307, France.<br /><searchLink fieldCode="AU" term="%22Hanak+AS%22">Hanak AS</searchLink>; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France.<br /><searchLink fieldCode="AU" term="%22Maryan-Instone+A%22">Maryan-Instone A</searchLink>; School of Chemistry and Chemical Engineering, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.<br /><searchLink fieldCode="AU" term="%22Gastellier+AJ%22">Gastellier AJ</searchLink>; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France.<br /><searchLink fieldCode="AU" term="%22Coisne+C%22">Coisne C</searchLink>; Université d'Artois (UArtois), UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Lens, F-62307, France.<br /><searchLink fieldCode="AU" term="%22Courageux+C%22">Courageux C</searchLink>; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France.<br /><searchLink fieldCode="AU" term="%22Hachani+J%22">Hachani J</searchLink>; Université d'Artois (UArtois), UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Lens, F-62307, France.<br /><searchLink fieldCode="AU" term="%22Gosselet+F%22">Gosselet F</searchLink>; Université d'Artois (UArtois), UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Lens, F-62307, France.<br /><searchLink fieldCode="AU" term="%22Dehouck+MP%22">Dehouck MP</searchLink>; Université d'Artois (UArtois), UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Lens, F-62307, France.<br /><searchLink fieldCode="AU" term="%22Rousseau+C%22">Rousseau C</searchLink>; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France.<br /><searchLink fieldCode="AU" term="%22Timperley+CM%22">Timperley CM</searchLink>; Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.<br /><searchLink fieldCode="AU" term="%22Weik+M%22">Weik M</searchLink>; Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, Grenoble, F-38000, France.<br /><searchLink fieldCode="AU" term="%22Nachon+F%22">Nachon F</searchLink>; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France.<br /><searchLink fieldCode="AU" term="%22Brown+RCD%22">Brown RCD</searchLink>; School of Chemistry and Chemical Engineering, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.<br /><searchLink fieldCode="AU" term="%22Baati+R%22">Baati R</searchLink>; École de Chimie Polymère et Matériaux ECPM, Université de Strasbourg, ICPEES UMR CNRS 7515, Strasbourg, F-67087, France.<br /><searchLink fieldCode="AU" term="%22Dias+J%22">Dias J</searchLink>; Institut de Recherche Biomédicale des Armées (IRBA), Département de Toxicologie et Risques Chimiques, Brétigny-sur-Orge, F-91220, France. Electronic address: jose.d@iasdef.gouv.fr. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Oct 15; Vol. 316, pp. 119023. <i>Date of Electronic Publication: </i>2026 Jun 01. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42241775 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ejmech.2026.119023 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 119023 Titles: – TitleFull: Design, synthesis and evaluation of an uncharged broad spectrum quinoline-oxime hybrid for the reactivation of nerve agent-inhibited human acetylcholinesterase. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: De Sousa J – PersonEntity: Name: NameFull: Calas AG – PersonEntity: Name: NameFull: De La Mora E – PersonEntity: Name: NameFull: Landry C – PersonEntity: Name: NameFull: Hanak AS – PersonEntity: Name: NameFull: Maryan-Instone A – PersonEntity: Name: NameFull: Gastellier AJ – PersonEntity: Name: NameFull: Coisne C – PersonEntity: Name: NameFull: Courageux C – PersonEntity: Name: NameFull: Hachani J – PersonEntity: Name: NameFull: Gosselet F – PersonEntity: Name: NameFull: Dehouck MP – PersonEntity: Name: NameFull: Rousseau C – PersonEntity: Name: NameFull: Timperley CM – PersonEntity: Name: NameFull: Weik M – PersonEntity: Name: NameFull: Nachon F – PersonEntity: Name: NameFull: Brown RCD – PersonEntity: Name: NameFull: Baati R – PersonEntity: Name: NameFull: Dias J IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 10 Text: 2026 Oct 15 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1768-3254 Numbering: – Type: volume Value: 316 Titles: – TitleFull: European journal of medicinal chemistry Type: main |
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