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A self-controlled case series to evaluate the effects of clinical trial eligibility criteria on biologic-associated reductions in severe asthma exacerbations: an analysis of the CHRONICLE Study.

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Title: A self-controlled case series to evaluate the effects of clinical trial eligibility criteria on biologic-associated reductions in severe asthma exacerbations: an analysis of the CHRONICLE Study.
Authors: Boakye-Dankwa E; Data Science and Advanced Analytics, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Kiddle SJ; Insight Generation, Data Science and Advanced Analytics, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK steven.kiddle@astrazeneca.com., Koo HN; Healthcare Analytics, Data Science and Advanced Analytics, BioPharmaceuticals R&D, Gothenburg, Sweden., Harper AR; Clinical Development, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Ambrose CS; BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA., Douglas IJ; Dept of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, UK., Quint JK; School of Public Health, Imperial College London, London, UK.
Source: The European respiratory journal [Eur Respir J] 2026 Jun 04. Date of Electronic Publication: 2026 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Boakye-Dankwa+E%22">Boakye-Dankwa E</searchLink>; Data Science and Advanced Analytics, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kiddle+SJ%22">Kiddle SJ</searchLink>; Insight Generation, Data Science and Advanced Analytics, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK steven.kiddle@astrazeneca.com.<br /><searchLink fieldCode="AU" term="%22Koo+HN%22">Koo HN</searchLink>; Healthcare Analytics, Data Science and Advanced Analytics, BioPharmaceuticals R&D, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Harper+AR%22">Harper AR</searchLink>; Clinical Development, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ambrose+CS%22">Ambrose CS</searchLink>; BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Douglas+IJ%22">Douglas IJ</searchLink>; Dept of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, UK.<br /><searchLink fieldCode="AU" term="%22Quint+JK%22">Quint JK</searchLink>; School of Public Health, Imperial College London, London, UK.
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  Data: <searchLink fieldCode="JN" term="%228803460%22">The European respiratory journal</searchLink> [Eur Respir J] 2026 Jun 04. <i>Date of Electronic Publication: </i>2026 Jun 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22European+Respiratory+Society%22">European Respiratory Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8803460 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1399-3003 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209031936%22">09031936 </searchLink><i>NLM ISO Abbreviation: </i>Eur Respir J <i>Subsets: </i>MEDLINE
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        Value: 10.1183/13993003.02196-2025
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              Text: 2026 Jun 04
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