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A first-in-human, open-label multicentre Phase 1 study of the orally administered E7386 in patients with selected advanced neoplasms.

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Title: A first-in-human, open-label multicentre Phase 1 study of the orally administered E7386 in patients with selected advanced neoplasms.
Authors: Evans TRJ; University of Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK. Thomas.Evans@glasgow.ac.uk., Cook N; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.; Division of Cancer Sciences, University of Manchester, Manchester, UK., El-Khoueiry A; Division of Medical Oncology, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Pinato DJ; Department of Surgery & Cancer, Imperial College London, London, UK.; Department of Translational Medicine, Division of Oncology, University of Piemonte Orientale, Novara, Italy., Tran NH; Department of Oncology, Mayo Clinic Comprehensive Cancer Center, Rochester, MN, USA., Hsiehchen D; Division of Hematology and Oncology, UT Southwestern Medical Center, Dallas, TX, USA., Mena E; Pasadena Liver Center, California Liver Research Institute, Pasadena, CA, USA., Meyer T; Research Department of Oncology, UCL Cancer Institute, University College London, London, UK.; Department of Oncology, Royal Free Hospital, London, UK., Wu J; Biostatics, Eisai Inc., Nutley, NJ, USA., Pathak SM; Clinical Pharmacology Science, Eisai Ltd, Hatfield, UK., Paoletti C; Clinical Research, Eisai Inc., Nutley, NJ, USA., Dutta L; Clinical Research, Eisai Inc., Nutley, NJ, USA., Okpara CE; Clinical Development, Eisai Ltd, Hatfield, UK., Lopez JS; Drug Development Unit, The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust, London, UK.
Source: British journal of cancer [Br J Cancer] 2026 Jun 04. Date of Electronic Publication: 2026 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Evans+TRJ%22">Evans TRJ</searchLink>; University of Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK. Thomas.Evans@glasgow.ac.uk.<br /><searchLink fieldCode="AU" term="%22Cook+N%22">Cook N</searchLink>; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.; Division of Cancer Sciences, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22El-Khoueiry+A%22">El-Khoueiry A</searchLink>; Division of Medical Oncology, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pinato+DJ%22">Pinato DJ</searchLink>; Department of Surgery & Cancer, Imperial College London, London, UK.; Department of Translational Medicine, Division of Oncology, University of Piemonte Orientale, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Tran+NH%22">Tran NH</searchLink>; Department of Oncology, Mayo Clinic Comprehensive Cancer Center, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hsiehchen+D%22">Hsiehchen D</searchLink>; Division of Hematology and Oncology, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Mena+E%22">Mena E</searchLink>; Pasadena Liver Center, California Liver Research Institute, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Meyer+T%22">Meyer T</searchLink>; Research Department of Oncology, UCL Cancer Institute, University College London, London, UK.; Department of Oncology, Royal Free Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Biostatics, Eisai Inc., Nutley, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Pathak+SM%22">Pathak SM</searchLink>; Clinical Pharmacology Science, Eisai Ltd, Hatfield, UK.<br /><searchLink fieldCode="AU" term="%22Paoletti+C%22">Paoletti C</searchLink>; Clinical Research, Eisai Inc., Nutley, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Dutta+L%22">Dutta L</searchLink>; Clinical Research, Eisai Inc., Nutley, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Okpara+CE%22">Okpara CE</searchLink>; Clinical Development, Eisai Ltd, Hatfield, UK.<br /><searchLink fieldCode="AU" term="%22Lopez+JS%22">Lopez JS</searchLink>; Drug Development Unit, The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust, London, UK.
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