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ApoE impairs microglial efferocytosis by targeting Gas6/MerTK in a mouse model of acute seizure.

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Title: ApoE impairs microglial efferocytosis by targeting Gas6/MerTK in a mouse model of acute seizure.
Authors: Gao B; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China., Cheng SM; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China., Zhang YY; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China., Yang HX; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China., Hu MM; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China., Wang Y; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China., Han JM; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China., Yu L; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China., Cao SZ; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China., Dong K; Department of Pharmacy, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, 230011, China., Kong H; Institute of Intelligent Machines, Chinese Academy of Science; University of Science and Technology of China, Hefei, 230026, China. kongh@ahmu.edu.cn.; Publishing Center of Anhui Medical University, Hefei, 230032, China. kongh@ahmu.edu.cn., Wu WN; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China. wuwn28@ahmu.edu.cn.; Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China. wuwn28@ahmu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jun 04. Date of Electronic Publication: 2026 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
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  Data: ApoE impairs microglial efferocytosis by targeting Gas6/MerTK in a mouse model of acute seizure.
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  Data: <searchLink fieldCode="AU" term="%22Gao+B%22">Gao B</searchLink>; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Cheng+SM%22">Cheng SM</searchLink>; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YY%22">Zhang YY</searchLink>; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Yang+HX%22">Yang HX</searchLink>; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Hu+MM%22">Hu MM</searchLink>; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Han+JM%22">Han JM</searchLink>; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Yu+L%22">Yu L</searchLink>; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Cao+SZ%22">Cao SZ</searchLink>; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Dong+K%22">Dong K</searchLink>; Department of Pharmacy, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, 230011, China.<br /><searchLink fieldCode="AU" term="%22Kong+H%22">Kong H</searchLink>; Institute of Intelligent Machines, Chinese Academy of Science; University of Science and Technology of China, Hefei, 230026, China. kongh@ahmu.edu.cn.; Publishing Center of Anhui Medical University, Hefei, 230032, China. kongh@ahmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wu+WN%22">Wu WN</searchLink>; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China. wuwn28@ahmu.edu.cn.; Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China. wuwn28@ahmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 Jun 04. <i>Date of Electronic Publication: </i>2026 Jun 04.
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        Value: 10.1038/s41401-026-01842-5
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              Text: 2026 Jun 04
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