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The antiphage mechanism of a widespread trypsin-MBL defense module.

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Title: The antiphage mechanism of a widespread trypsin-MBL defense module.
Authors: Huang P; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China., Liu J; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Guo L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China., Xu D; Institute of Genomics, School of Medicine, Huaqiao University, Xiamen, China., Shen L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Yan P; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Tong C; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Fei W; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Cheng M; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China., Li Z; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China., Lu M; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China.; Department of Biochemistry, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China., Zhang L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China., Wu N; Fudan University Phage Institute, Zhongshan Hospital Fudan University, Shanghai, China. nannan.wu@cphage.com.; CreatiPhage Biotechnology, Ltd., Co., Shanghai, China. nannan.wu@cphage.com., Qi LW; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. Qilw@cpu.edu.cn.; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. Qilw@cpu.edu.cn.; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China. Qilw@cpu.edu.cn.; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China. Qilw@cpu.edu.cn., Xiao Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. yibei.xiao@cpu.edu.cn.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China. yibei.xiao@cpu.edu.cn.; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China. yibei.xiao@cpu.edu.cn., Chen M; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. chenmr@cpu.edu.cn.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China. chenmr@cpu.edu.cn.; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China. chenmr@cpu.edu.cn.
Source: Nature chemical biology [Nat Chem Biol] 2026 Jun 04. Date of Electronic Publication: 2026 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: The antiphage mechanism of a widespread trypsin-MBL defense module.
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  Data: <searchLink fieldCode="AU" term="%22Huang+P%22">Huang P</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Guo+L%22">Guo L</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xu+D%22">Xu D</searchLink>; Institute of Genomics, School of Medicine, Huaqiao University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Shen+L%22">Shen L</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Yan+P%22">Yan P</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Tong+C%22">Tong C</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Fei+W%22">Fei W</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Cheng+M%22">Cheng M</searchLink>; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Lu+M%22">Lu M</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China.; Department of Biochemistry, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Wu+N%22">Wu N</searchLink>; Fudan University Phage Institute, Zhongshan Hospital Fudan University, Shanghai, China. nannan.wu@cphage.com.; CreatiPhage Biotechnology, Ltd., Co., Shanghai, China. nannan.wu@cphage.com.<br /><searchLink fieldCode="AU" term="%22Qi+LW%22">Qi LW</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. Qilw@cpu.edu.cn.; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. Qilw@cpu.edu.cn.; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China. Qilw@cpu.edu.cn.; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China. Qilw@cpu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xiao+Y%22">Xiao Y</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. yibei.xiao@cpu.edu.cn.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China. yibei.xiao@cpu.edu.cn.; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China. yibei.xiao@cpu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. chenmr@cpu.edu.cn.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China. chenmr@cpu.edu.cn.; Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China. chenmr@cpu.edu.cn.
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