Pediatric oral cavity physiologically based pharmacokinetic model to predict pharmacokinetics of mucoadhesive atropine gel to treat sialorrhea.

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Bibliographic Details
Title: Pediatric oral cavity physiologically based pharmacokinetic model to predict pharmacokinetics of mucoadhesive atropine gel to treat sialorrhea.
Authors: Parrot M; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA.; Department of Molecular Pharmaceutics, Utah Center for Nanomedicine, College of Pharmacy, University of Utah, Salt Lake City, UT, USA., Murphy N; Division of Complex Care, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA., Rower JE; Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., Reilly CA; Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., Green D; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA., Tarrell A; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA.; Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA., Watt K; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA., Yellepeddi V; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA. venkata.yellepeddi@hsc.utah.edu.; Department of Molecular Pharmaceutics, Utah Center for Nanomedicine, College of Pharmacy, University of Utah, Salt Lake City, UT, USA. venkata.yellepeddi@hsc.utah.edu.
Source: Journal of pharmacokinetics and pharmacodynamics [J Pharmacokinet Pharmacodyn] 2026 Jun 04; Vol. 53 (4). Date of Electronic Publication: 2026 Jun 04.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101096520 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-8744 (Electronic) Linking ISSN: 1567567X NLM ISO Abbreviation: J Pharmacokinet Pharmacodyn Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1573-8744
DOI:10.1007/s10928-026-10039-6