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Pediatric oral cavity physiologically based pharmacokinetic model to predict pharmacokinetics of mucoadhesive atropine gel to treat sialorrhea.

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Title: Pediatric oral cavity physiologically based pharmacokinetic model to predict pharmacokinetics of mucoadhesive atropine gel to treat sialorrhea.
Authors: Parrot M; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA.; Department of Molecular Pharmaceutics, Utah Center for Nanomedicine, College of Pharmacy, University of Utah, Salt Lake City, UT, USA., Murphy N; Division of Complex Care, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA., Rower JE; Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., Reilly CA; Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., Green D; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA., Tarrell A; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA.; Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA., Watt K; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA., Yellepeddi V; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA. venkata.yellepeddi@hsc.utah.edu.; Department of Molecular Pharmaceutics, Utah Center for Nanomedicine, College of Pharmacy, University of Utah, Salt Lake City, UT, USA. venkata.yellepeddi@hsc.utah.edu.
Source: Journal of pharmacokinetics and pharmacodynamics [J Pharmacokinet Pharmacodyn] 2026 Jun 04; Vol. 53 (4). Date of Electronic Publication: 2026 Jun 04.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101096520 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-8744 (Electronic) Linking ISSN: 1567567X NLM ISO Abbreviation: J Pharmacokinet Pharmacodyn Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
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  Data: Pediatric oral cavity physiologically based pharmacokinetic model to predict pharmacokinetics of mucoadhesive atropine gel to treat sialorrhea.
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  Data: <searchLink fieldCode="AU" term="%22Parrot+M%22">Parrot M</searchLink>; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA.; Department of Molecular Pharmaceutics, Utah Center for Nanomedicine, College of Pharmacy, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+N%22">Murphy N</searchLink>; Division of Complex Care, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Rower+JE%22">Rower JE</searchLink>; Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Reilly+CA%22">Reilly CA</searchLink>; Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Green+D%22">Green D</searchLink>; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA.<br /><searchLink fieldCode="AU" term="%22Tarrell+A%22">Tarrell A</searchLink>; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA.; Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Watt+K%22">Watt K</searchLink>; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA.<br /><searchLink fieldCode="AU" term="%22Yellepeddi+V%22">Yellepeddi V</searchLink>; Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, 295 Chipeta Way, Rm#1S132, Salt Lake City, UT, 84108, USA. venkata.yellepeddi@hsc.utah.edu.; Department of Molecular Pharmaceutics, Utah Center for Nanomedicine, College of Pharmacy, University of Utah, Salt Lake City, UT, USA. venkata.yellepeddi@hsc.utah.edu.
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  Data: <searchLink fieldCode="JN" term="%22101096520%22">Journal of pharmacokinetics and pharmacodynamics</searchLink> [J Pharmacokinet Pharmacodyn] 2026 Jun 04; Vol. 53 (4). <i>Date of Electronic Publication: </i>2026 Jun 04.
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  Data: Journal Article; Clinical Trial, Phase I
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101096520 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-8744 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221567567X%22">1567567X </searchLink><i>NLM ISO Abbreviation: </i>J Pharmacokinet Pharmacodyn <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10928-026-10039-6
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        Text: English
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            – D: 04
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              Text: 2026 Jun 04
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              Y: 2026
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