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Restoring Septohippocampal Cholinergic Signaling Rescues Surgery-Induced Neurogenesis and Memory Deficits in Aged Mice.

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Title: Restoring Septohippocampal Cholinergic Signaling Rescues Surgery-Induced Neurogenesis and Memory Deficits in Aged Mice.
Authors: Lei L; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Province International Joint Laboratory of Pain, Cognition, and Emotion, Zhengzhou, China., Meng Q; Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China., Hu X; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Yang J; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Province International Joint Laboratory of Pain, Cognition, and Emotion, Zhengzhou, China., Du N; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Su S; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China., Hashimoto K; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Center for Forensic Mental Health, Chiba University, Chiba, Japan., Cao J; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China., Yang JJ; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Province International Joint Laboratory of Pain, Cognition, and Emotion, Zhengzhou, China.
Source: Aging cell [Aging Cell] 2026 Jun; Vol. 25 (6), pp. e70574.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Restoring Septohippocampal Cholinergic Signaling Rescues Surgery-Induced Neurogenesis and Memory Deficits in Aged Mice.
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  Data: <searchLink fieldCode="AU" term="%22Lei+L%22">Lei L</searchLink>; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Province International Joint Laboratory of Pain, Cognition, and Emotion, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Meng+Q%22">Meng Q</searchLink>; Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Province International Joint Laboratory of Pain, Cognition, and Emotion, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Du+N%22">Du N</searchLink>; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Su+S%22">Su S</searchLink>; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Hashimoto+K%22">Hashimoto K</searchLink>; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Center for Forensic Mental Health, Chiba University, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Cao+J%22">Cao J</searchLink>; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+JJ%22">Yang JJ</searchLink>; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Province International Joint Laboratory of Pain, Cognition, and Emotion, Zhengzhou, China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101130839 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-9726 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214749718%22">14749718 </searchLink><i>NLM ISO Abbreviation: </i>Aging Cell <i>Subsets: </i>MEDLINE
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        Value: 10.1111/acel.70574
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        Text: English
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            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
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