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Optimization of stapled peptide inhibitors reveals design principles for targeting talin-induced integrin activation.

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Title: Optimization of stapled peptide inhibitors reveals design principles for targeting talin-induced integrin activation.
Authors: Gao T; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA., Belova E; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.; Bioengineering Department, Temple University, Philadelphia, PA, USA., Mori Y; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA., Deni WH; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA., Roder H; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA., Gligorijevic B; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.; Bioengineering Department, Temple University, Philadelphia, PA, USA., Wu J; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 27. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 42244552
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Optimization of stapled peptide inhibitors reveals design principles for targeting talin-induced integrin activation.
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  Data: <searchLink fieldCode="AU" term="%22Gao+T%22">Gao T</searchLink>; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.<br /><searchLink fieldCode="AU" term="%22Belova+E%22">Belova E</searchLink>; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.; Bioengineering Department, Temple University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mori+Y%22">Mori Y</searchLink>; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.<br /><searchLink fieldCode="AU" term="%22Deni+WH%22">Deni WH</searchLink>; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.<br /><searchLink fieldCode="AU" term="%22Roder+H%22">Roder H</searchLink>; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.<br /><searchLink fieldCode="AU" term="%22Gligorijevic+B%22">Gligorijevic B</searchLink>; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.; Bioengineering Department, Temple University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 May 27. <i>Date of Electronic Publication: </i>2026 May 27.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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      – Type: doi
        Value: 10.64898/2026.05.25.727761
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        Text: English
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      – TitleFull: Optimization of stapled peptide inhibitors reveals design principles for targeting talin-induced integrin activation.
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              Text: 2026 May 27
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