The Structural Basis of Malodorant Skatole Formation by the Glycyl Radical Enzyme Indoleacetate Decarboxylase.

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Title: The Structural Basis of Malodorant Skatole Formation by the Glycyl Radical Enzyme Indoleacetate Decarboxylase.
Authors: Imrich CN; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 USA., Backman LRF; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Present address: The Whitehead Institute for Biomedical Research, Cambridge, MA 02142 USA., Allworth AP; MIT Summer Research Program in Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA., Andorfer MC; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Present Address: Department of Chemistry, Michigan State University, East Lansing, MI 48824 USA., Paris JC; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA., Greeley NM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 USA., Fu B; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.; Broad Institute, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Cambridge, MA 02139 USA., Drennan CL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, Cambridge, MA 02139 USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 25. Date of Electronic Publication: 2026 May 25.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Imrich+CN%22">Imrich CN</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.<br /><searchLink fieldCode="AU" term="%22Backman+LRF%22">Backman LRF</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Present address: The Whitehead Institute for Biomedical Research, Cambridge, MA 02142 USA.<br /><searchLink fieldCode="AU" term="%22Allworth+AP%22">Allworth AP</searchLink>; MIT Summer Research Program in Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.<br /><searchLink fieldCode="AU" term="%22Andorfer+MC%22">Andorfer MC</searchLink>; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Present Address: Department of Chemistry, Michigan State University, East Lansing, MI 48824 USA.<br /><searchLink fieldCode="AU" term="%22Paris+JC%22">Paris JC</searchLink>; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.<br /><searchLink fieldCode="AU" term="%22Greeley+NM%22">Greeley NM</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.<br /><searchLink fieldCode="AU" term="%22Fu+B%22">Fu B</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.<br /><searchLink fieldCode="AU" term="%22Balskus+EP%22">Balskus EP</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.; Broad Institute, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Cambridge, MA 02139 USA.<br /><searchLink fieldCode="AU" term="%22Drennan+CL%22">Drennan CL</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, Cambridge, MA 02139 USA.
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