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Phage RyR-domain proteins degrade ADPR-based immune signals and fuel NAD+ synthesis.

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Title: Phage RyR-domain proteins degrade ADPR-based immune signals and fuel NAD+ synthesis.
Authors: López Rivera M; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Chang RB; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Lewis CM; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA., Hadary R; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel., Kovalski JM; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA., Freeman KG; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA., Sun ZJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Sorek R; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel., Hatfull GF; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA., Kranzusch PJ; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 29. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Phage RyR-domain proteins degrade ADPR-based immune signals and fuel NAD<superscript>+</superscript> synthesis.
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  Data: <searchLink fieldCode="AU" term="%22López+Rivera+M%22">López Rivera M</searchLink>; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Chang+RB%22">Chang RB</searchLink>; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+CM%22">Lewis CM</searchLink>; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.<br /><searchLink fieldCode="AU" term="%22Hadary+R%22">Hadary R</searchLink>; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Kovalski+JM%22">Kovalski JM</searchLink>; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.<br /><searchLink fieldCode="AU" term="%22Freeman+KG%22">Freeman KG</searchLink>; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.<br /><searchLink fieldCode="AU" term="%22Sun+ZJ%22">Sun ZJ</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sorek+R%22">Sorek R</searchLink>; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Hatfull+GF%22">Hatfull GF</searchLink>; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.<br /><searchLink fieldCode="AU" term="%22Kranzusch+PJ%22">Kranzusch PJ</searchLink>; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute, Boston, MA 02115, USA.
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