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GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions.

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Title: GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions.
Authors: Madriles F; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain., de Andres MP; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain., Chesnokov M; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain., Martinez de Villarreal J; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain., Alonso-Curbelo D; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Del Pozo N; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain., Iglesias M; Department of Pathology, Parc de Salut Mar, Barcelona, Spain., Carrillo-de-Santa-Pau E; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain., Iovanna J; Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Marseille, France., Soriano F; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Cuadrado A; Chromosome Dynamics Group, Molecular Oncology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Marques M; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain., Muñoz J; Proteomics Unit, Biotechnology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Esposito I; Institute of Pathology, Heinrich-Heine University & University Hospital, Duesseldorf, Germany., Martinelli P; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Lowe SW; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Real FX; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain.; Departament de Medicina i Ciències de la Vida, Universitat Pompeu Fabra, Barcelona, Spain.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 26. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions.
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  Data: <searchLink fieldCode="AU" term="%22Madriles+F%22">Madriles F</searchLink>; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22de+Andres+MP%22">de Andres MP</searchLink>; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Chesnokov+M%22">Chesnokov M</searchLink>; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez+de+Villarreal+J%22">Martinez de Villarreal J</searchLink>; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Alonso-Curbelo+D%22">Alonso-Curbelo D</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Del+Pozo+N%22">Del Pozo N</searchLink>; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Iglesias+M%22">Iglesias M</searchLink>; Department of Pathology, Parc de Salut Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Carrillo-de-Santa-Pau+E%22">Carrillo-de-Santa-Pau E</searchLink>; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Iovanna+J%22">Iovanna J</searchLink>; Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Soriano+F%22">Soriano F</searchLink>; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cuadrado+A%22">Cuadrado A</searchLink>; Chromosome Dynamics Group, Molecular Oncology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Marques+M%22">Marques M</searchLink>; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Muñoz+J%22">Muñoz J</searchLink>; Proteomics Unit, Biotechnology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Esposito+I%22">Esposito I</searchLink>; Institute of Pathology, Heinrich-Heine University & University Hospital, Duesseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Martinelli+P%22">Martinelli P</searchLink>; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lowe+SW%22">Lowe SW</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Real+FX%22">Real FX</searchLink>; Epithelial Carcinogenesis Group, Tumor Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; CIBERONC, Madrid, Spain.; Departament de Medicina i Ciències de la Vida, Universitat Pompeu Fabra, Barcelona, Spain.
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