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Therapeutic pressure drives the evolution of a protective ecotype characterized by AR-loss-induced senescence in prostate cancer.

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Title: Therapeutic pressure drives the evolution of a protective ecotype characterized by AR-loss-induced senescence in prostate cancer.
Authors: He L; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.; Department of Urology, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, China., Jiang J; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.; Department of Health Service, Base of Health Service, Air Force Medical University, Xi'an, China., Liu S; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Song H; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Lu T; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Hu Z; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Li Y; Department of Urology, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing, China., Zhu H; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Zhou Y; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Li Z; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Yang F; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Zhang K; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Zhang R; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Wu T; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Gan K; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Zhao B; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Zhang J; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Si D; Military Medical Innovation Center, Air Force Medical University, Xi'an, China., Zhang R; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Immunology, Air Force Medical University, Xi'an, China., Shi C; Division of Cancer Biology, Laboratory Animal Center, Air Force Medical University, Xi'an, China., Wen W; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, China., Han D; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Xu C; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China., Qin W; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.
Source: Theranostics [Theranostics] 2026 May 11; Vol. 16 (12), pp. 6803-6826. Date of Electronic Publication: 2026 May 11 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22He+L%22">He L</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.; Department of Urology, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Jiang+J%22">Jiang J</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.; Department of Health Service, Base of Health Service, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Song+H%22">Song H</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Lu+T%22">Lu T</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Hu+Z%22">Hu Z</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Urology, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zhu+H%22">Zhu H</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Yang+F%22">Yang F</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Zhang+K%22">Zhang K</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Wu+T%22">Wu T</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Gan+K%22">Gan K</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Zhao+B%22">Zhao B</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Si+D%22">Si D</searchLink>; Military Medical Innovation Center, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Immunology, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Shi+C%22">Shi C</searchLink>; Division of Cancer Biology, Laboratory Animal Center, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Wen+W%22">Wen W</searchLink>; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Han+D%22">Han D</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Qin+W%22">Qin W</searchLink>; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.
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  Data: <searchLink fieldCode="JN" term="%22101552395%22">Theranostics</searchLink> [Theranostics] 2026 May 11; Vol. 16 (12), pp. 6803-6826. <i>Date of Electronic Publication: </i>2026 May 11 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ivyspring+International+Publisher%22">Ivyspring International Publisher </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>101552395 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1838-7640 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218387640%22">18387640 </searchLink><i>NLM ISO Abbreviation: </i>Theranostics <i>Subsets: </i>MEDLINE
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