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Intratumoral TLR4 agonist therapy elicits antigen-specific T cell clonal expansion in metastatic leiomyosarcoma: a case series.

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Title: Intratumoral TLR4 agonist therapy elicits antigen-specific T cell clonal expansion in metastatic leiomyosarcoma: a case series.
Authors: Zhang JS; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Ng JCK; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Hermida de Viveiros P; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Al-Marayaty R; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Al Akoum N; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Shinglot H; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Jing W; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Vizcaino V; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Alexiev BA; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Cranmer LD; Department of Medicine, City of Hope Cancer Center, Los Angeles, CA, United States., Loggers ET; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, United States., Abrams H; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, United States., Wagner MJ; Sarcoma Center, Dana Farber Cancer Institute, Boston, MA, United States., Pillarisetty VG; Department of Surgery, University of Washington, Seattle, WA, United States., Kim EY; Department of Radiation Oncology, University of Washington, Seattle, WA, United States., Pierce RH; Attivare, Natick, MA, United States., Berglund P; HDT Bio, Seattle, WA, United States., Jones RL; Royal Marsden and Institute for Cancer Research, London, United Kingdom., Lu H; Pfizer, Bothell, WA, United States., Ter Meulen J; Obsidian Therapeutics, Cambridge, MA, United States., Pollack SM; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Seo YD; Department of Surgery, University of Washington, Seattle, WA, United States.; Department of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI, United States.
Source: Frontiers in oncology [Front Oncol] 2026 May 20; Vol. 16, pp. 1829331. Date of Electronic Publication: 2026 May 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Intratumoral TLR4 agonist therapy elicits antigen-specific T cell clonal expansion in metastatic leiomyosarcoma: a case series.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+JS%22">Zhang JS</searchLink>; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Ng+JCK%22">Ng JCK</searchLink>; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Hermida+de+Viveiros+P%22">Hermida de Viveiros P</searchLink>; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Al-Marayaty+R%22">Al-Marayaty R</searchLink>; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Al+Akoum+N%22">Al Akoum N</searchLink>; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Shinglot+H%22">Shinglot H</searchLink>; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Jing+W%22">Jing W</searchLink>; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Vizcaino+V%22">Vizcaino V</searchLink>; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Alexiev+BA%22">Alexiev BA</searchLink>; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Cranmer+LD%22">Cranmer LD</searchLink>; Department of Medicine, City of Hope Cancer Center, Los Angeles, CA, United States.<br /><searchLink fieldCode="AU" term="%22Loggers+ET%22">Loggers ET</searchLink>; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Abrams+H%22">Abrams H</searchLink>; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Wagner+MJ%22">Wagner MJ</searchLink>; Sarcoma Center, Dana Farber Cancer Institute, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Pillarisetty+VG%22">Pillarisetty VG</searchLink>; Department of Surgery, University of Washington, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Kim+EY%22">Kim EY</searchLink>; Department of Radiation Oncology, University of Washington, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Pierce+RH%22">Pierce RH</searchLink>; Attivare, Natick, MA, United States.<br /><searchLink fieldCode="AU" term="%22Berglund+P%22">Berglund P</searchLink>; HDT Bio, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Jones+RL%22">Jones RL</searchLink>; Royal Marsden and Institute for Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lu+H%22">Lu H</searchLink>; Pfizer, Bothell, WA, United States.<br /><searchLink fieldCode="AU" term="%22Ter+Meulen+J%22">Ter Meulen J</searchLink>; Obsidian Therapeutics, Cambridge, MA, United States.<br /><searchLink fieldCode="AU" term="%22Pollack+SM%22">Pollack SM</searchLink>; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Seo+YD%22">Seo YD</searchLink>; Department of Surgery, University of Washington, Seattle, WA, United States.; Department of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI, United States.
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  Data: <searchLink fieldCode="JN" term="%22101568867%22">Frontiers in oncology</searchLink> [Front Oncol] 2026 May 20; Vol. 16, pp. 1829331. <i>Date of Electronic Publication: </i>2026 May 20 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101568867 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2234-943X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222234943X%22">2234943X </searchLink><i>NLM ISO Abbreviation: </i>Front Oncol <i>Subsets: </i>PubMed not MEDLINE
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