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BCL-2 and MCL1 co-inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A-rearranged acute lymphoblastic leukaemia.

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Title: BCL-2 and MCL1 co-inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A-rearranged acute lymphoblastic leukaemia.
Authors: Karsa M; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Karsa A; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia., Spurling D; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia., Xiao L; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Ronca E; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia., Bongers A; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia., Gao W; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Gifford AJ; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.; Anatomical Pathology, NSW Health Pathology, Prince of Wales Hospital, Randwick, New South Wales, Australia., El-Ayoubi A; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia., Cheung LC; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia, Perth, Western Australia, Australia.; Curtin Medical School, Curtin University, Perth, Western Australia, Australia.; Curtin Medical Research Institute, Curtin University, Perth, Western Australia, Australia., Kotecha RS; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia, Perth, Western Australia, Australia.; Curtin Medical School, Curtin University, Perth, Western Australia, Australia.; Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Western Australia, Australia.; Medical School, University of Western Australia, Perth, Western Australia, Australia., Lock RB; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Teh CE; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Lessene G; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia., Norris MD; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Wei A; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Haber M; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Henderson MJ; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia., Moujalled DM; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Somers K; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.
Source: British journal of haematology [Br J Haematol] 2026 Jun 05. Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE
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  Data: BCL-2 and MCL1 co-inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A-rearranged acute lymphoblastic leukaemia.
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  Data: <searchLink fieldCode="AU" term="%22Karsa+M%22">Karsa M</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Karsa+A%22">Karsa A</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Spurling+D%22">Spurling D</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Xiao+L%22">Xiao L</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Ronca+E%22">Ronca E</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Bongers+A%22">Bongers A</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Gao+W%22">Gao W</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Gifford+AJ%22">Gifford AJ</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.; Anatomical Pathology, NSW Health Pathology, Prince of Wales Hospital, Randwick, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22El-Ayoubi+A%22">El-Ayoubi A</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Cheung+LC%22">Cheung LC</searchLink>; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia, Perth, Western Australia, Australia.; Curtin Medical School, Curtin University, Perth, Western Australia, Australia.; Curtin Medical Research Institute, Curtin University, Perth, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Kotecha+RS%22">Kotecha RS</searchLink>; Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia, Perth, Western Australia, Australia.; Curtin Medical School, Curtin University, Perth, Western Australia, Australia.; Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Western Australia, Australia.; Medical School, University of Western Australia, Perth, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Lock+RB%22">Lock RB</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Teh+CE%22">Teh CE</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lessene+G%22">Lessene G</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Norris+MD%22">Norris MD</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Wei+A%22">Wei A</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Haber+M%22">Haber M</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Henderson+MJ%22">Henderson MJ</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Moujalled+DM%22">Moujalled DM</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Somers+K%22">Somers K</searchLink>; Children's Cancer Institute at Minderoo Children's Comprehensive Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.
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