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High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.

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Title: High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.
Authors: Yang D; Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, ON M1C 1A4, Canada., Wang X; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada., Liu J; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.; Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada., Gong Y; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada., Nair P; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada., Sun J; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada., Qian X; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada., Cui J; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada., Zeng H; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada., Dong A; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada., Harding RJ; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5G 2C8, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada., Burgess-Brown N; Structural Genomics Consortium, University College London, London WC1N 1AX, United Kingdom., Beyett TS; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA 30322., Song D; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada., Krause HM; Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada., Diamond ML; School of the Environment, University of Toronto, Toronto, ON M5S 3E8, Canada.; Department of Earth Sciences, University of Toronto, Toronto, ON M5S 3B1, Canada., Bolhuis DL; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599., Brown NG; Pharmacology Department, University of North Carolina, Chapel Hill, NC 27599., Arrowsmith CH; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Edwards AM; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada., Halabelian L; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5G 2C8, Canada., Peng H; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada.; School of the Environment, University of Toronto, Toronto, ON M5S 3E8, Canada.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 23; Vol. 123 (25), pp. e2515940123. Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Yang+D%22">Yang D</searchLink>; Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, ON M1C 1A4, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.; Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.<br /><searchLink fieldCode="AU" term="%22Gong+Y%22">Gong Y</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.<br /><searchLink fieldCode="AU" term="%22Nair+P%22">Nair P</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Qian+X%22">Qian X</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.<br /><searchLink fieldCode="AU" term="%22Cui+J%22">Cui J</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.<br /><searchLink fieldCode="AU" term="%22Zeng+H%22">Zeng H</searchLink>; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Dong+A%22">Dong A</searchLink>; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Harding+RJ%22">Harding RJ</searchLink>; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5G 2C8, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.<br /><searchLink fieldCode="AU" term="%22Burgess-Brown+N%22">Burgess-Brown N</searchLink>; Structural Genomics Consortium, University College London, London WC1N 1AX, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Beyett+TS%22">Beyett TS</searchLink>; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA 30322.<br /><searchLink fieldCode="AU" term="%22Song+D%22">Song D</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.<br /><searchLink fieldCode="AU" term="%22Krause+HM%22">Krause HM</searchLink>; Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.<br /><searchLink fieldCode="AU" term="%22Diamond+ML%22">Diamond ML</searchLink>; School of the Environment, University of Toronto, Toronto, ON M5S 3E8, Canada.; Department of Earth Sciences, University of Toronto, Toronto, ON M5S 3B1, Canada.<br /><searchLink fieldCode="AU" term="%22Bolhuis+DL%22">Bolhuis DL</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Brown+NG%22">Brown NG</searchLink>; Pharmacology Department, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Arrowsmith+CH%22">Arrowsmith CH</searchLink>; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Edwards+AM%22">Edwards AM</searchLink>; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Halabelian+L%22">Halabelian L</searchLink>; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5G 2C8, Canada.<br /><searchLink fieldCode="AU" term="%22Peng+H%22">Peng H</searchLink>; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.; Structural Genomics Consortium, Toronto, ON M5G 1L7, Canada.; School of the Environment, University of Toronto, Toronto, ON M5S 3E8, Canada.
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