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Inhibiting glycan degradation prevents HIV-induced inflammaging and cognitive impairment.

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Title: Inhibiting glycan degradation prevents HIV-induced inflammaging and cognitive impairment.
Authors: Giron LB; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Borjabad A; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hadas E; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Granche J; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Marques de Menezes EG; Vitalant Research Institute, San Francisco, CA 94105, USA; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA., Premeaux TA; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA., He H; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Yeung ST; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA., Singh S; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Friday C; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA., Glover J; Stem Cell and Xenograft Core, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Balboa E; Stem Cell and Xenograft Core, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Dopkin D; Stem Cell and Xenograft Core, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Burrows M; Stem Cell and Xenograft Core, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Secreto A; Stem Cell and Xenograft Core, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Skuli N; Stem Cell and Xenograft Core, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Tateno H; Cellular and Molecular Biotechnology Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan., Denton PW; Department of Biology, University of Nebraska Omaha, Omaha, NE 68182, USA., Palella F; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Corley MJ; Division of Geriatrics, Gerontology & Palliative Care, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Ndhlovu LC; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA., Norris PJ; Vitalant Research Institute, San Francisco, CA 94105, USA; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA., Tassiopoulos K; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Volsky DJ; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: david.volsky@mssm.edu., Abdel-Mohsen M; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: mmohsen@northwestern.edu.
Source: Med (New York, N.Y.) [Med] 2026 Jul 10; Vol. 7 (7), pp. 101175. Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101769215 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-6340 (Electronic) Linking ISSN: 26666340 NLM ISO Abbreviation: Med Subsets: MEDLINE
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  Data: Inhibiting glycan degradation prevents HIV-induced inflammaging and cognitive impairment.
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  Data: <searchLink fieldCode="AU" term="%22Giron+LB%22">Giron LB</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Borjabad+A%22">Borjabad A</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Hadas+E%22">Hadas E</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Granche+J%22">Granche J</searchLink>; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Marques+de+Menezes+EG%22">Marques de Menezes EG</searchLink>; Vitalant Research Institute, San Francisco, CA 94105, USA; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Premeaux+TA%22">Premeaux TA</searchLink>; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22He+H%22">He H</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Yeung+ST%22">Yeung ST</searchLink>; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Friday+C%22">Friday C</searchLink>; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Glover+J%22">Glover J</searchLink>; Stem Cell and Xenograft Core, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Balboa+E%22">Balboa E</searchLink>; Stem Cell and Xenograft Core, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Dopkin+D%22">Dopkin D</searchLink>; Stem Cell and Xenograft Core, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Burrows+M%22">Burrows M</searchLink>; Stem Cell and Xenograft Core, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Secreto+A%22">Secreto A</searchLink>; Stem Cell and Xenograft Core, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Skuli+N%22">Skuli N</searchLink>; Stem Cell and Xenograft Core, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Tateno+H%22">Tateno H</searchLink>; Cellular and Molecular Biotechnology Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan.<br /><searchLink fieldCode="AU" term="%22Denton+PW%22">Denton PW</searchLink>; Department of Biology, University of Nebraska Omaha, Omaha, NE 68182, USA.<br /><searchLink fieldCode="AU" term="%22Palella+F%22">Palella F</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Corley+MJ%22">Corley MJ</searchLink>; Division of Geriatrics, Gerontology & Palliative Care, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Ndhlovu+LC%22">Ndhlovu LC</searchLink>; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Norris+PJ%22">Norris PJ</searchLink>; Vitalant Research Institute, San Francisco, CA 94105, USA; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Tassiopoulos+K%22">Tassiopoulos K</searchLink>; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Volsky+DJ%22">Volsky DJ</searchLink>; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: david.volsky@mssm.edu.<br /><searchLink fieldCode="AU" term="%22Abdel-Mohsen+M%22">Abdel-Mohsen M</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: mmohsen@northwestern.edu.
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