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Strain-promoted click chemistry boosts microbubbles for targeted ultrasound imaging and cancer chemotherapy.

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Title: Strain-promoted click chemistry boosts microbubbles for targeted ultrasound imaging and cancer chemotherapy.
Authors: Zhang X; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China., Lu Y; Department of General Surgery, Center for Metabolism Research, The Fourth Affiliated Hospital of Zhejiang University School of Medicine and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China., Wu X; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China., Zhu W; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China., Li R; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China., Shan Q; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China., Jiang S; Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University, Sturt Road, Bedford Park, South Australia 5042, Australia., Xia X; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China., Ying B; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China., Shen M; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China., Xu Z; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China., Wang S; School of Engineering, Qinghai Institute of Technology, Xining 810016, China. Electronic address: sjwang@qhit.edu.cn., Zhang K; School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address: kaizhang@zstu.edu.cn., Chen J; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China; School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address: chenjianzuj4h@zju.edu.cn.
Source: Acta biomaterialia [Acta Biomater] 2026 Jul; Vol. 218, pp. 510-524. Date of Electronic Publication: 2026 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of General Surgery, Center for Metabolism Research, The Fourth Affiliated Hospital of Zhejiang University School of Medicine and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.<br /><searchLink fieldCode="AU" term="%22Zhu+W%22">Zhu W</searchLink>; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.<br /><searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.<br /><searchLink fieldCode="AU" term="%22Shan+Q%22">Shan Q</searchLink>; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.<br /><searchLink fieldCode="AU" term="%22Jiang+S%22">Jiang S</searchLink>; Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University, Sturt Road, Bedford Park, South Australia 5042, Australia.<br /><searchLink fieldCode="AU" term="%22Xia+X%22">Xia X</searchLink>; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.<br /><searchLink fieldCode="AU" term="%22Ying+B%22">Ying B</searchLink>; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.<br /><searchLink fieldCode="AU" term="%22Shen+M%22">Shen M</searchLink>; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; School of Engineering, Qinghai Institute of Technology, Xining 810016, China. Electronic address: sjwang@qhit.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+K%22">Zhang K</searchLink>; School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address: kaizhang@zstu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Ultrasound in Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China; School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address: chenjianzuj4h@zju.edu.cn.
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        Value: 10.1016/j.actbio.2026.06.005
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              Text: 2026 Jul
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