Combining Behavioral Activation and repetitive Transcranial magnetic stimulation in Late-Life Depression (COMBAT-LLD study): Study protocol for a randomized controlled trial.

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Title: Combining Behavioral Activation and repetitive Transcranial magnetic stimulation in Late-Life Depression (COMBAT-LLD study): Study protocol for a randomized controlled trial.
Authors: de Wijs I; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain Cognition and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands. Electronic address: Imke.deWijs@radboudumc.nl., Tendolkar I; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain Cognition and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands., van Beek MHCT; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain Cognition and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands., van Belkum S; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Dalhuisen I; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain Cognition and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands., Dlabac-de Lange JJ; GGZ Centraal Mental Health Care, Amersfoort, the Netherlands., van Eijndhoven P; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain Cognition and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands., van Exel E; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; GGZ inGeest Mental Health Care, Amsterdam, the Netherlands., Houwert-Zuidema M; GGZ Centraal Mental Health Care, Amersfoort, the Netherlands., Jeuring HW; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Kool RB; Radboud University Medical Center, IQ Health Science Department, Nijmegen, the Netherlands., Legemaat A; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands., Oostelbos P; Depression Association, Randwijk, the Netherlands., Rhebergen D; GGZ Centraal Mental Health Care, Amersfoort, the Netherlands; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; GGZ inGeest Mental Health Care, Amsterdam, the Netherlands., van Velsen H; Focus Group Samen Sterker, the Netherlands., Wijnen B; Centre for Economic Evaluation, Trimbos Institute (Netherlands Institute of Mental Health and Addiction), Utrecht, the Netherlands., Hendriks GJ; 'Overwaal' Centre of Expertise for Anxiety Disorders, OCD & PTSD, Pro Persona, Institute of Integrated Mental Health Care, Nijmegen, the Netherlands; Behavioral Science Institute, Radboud University, Nijmegen, the Netherlands., Carlier A; Behavioral Science Institute, Radboud University, Nijmegen, the Netherlands; Maria Mackenzie Expertise Center for Old Age Psychiatry, Pro Persona Mental Health Care, Nijmegen, the Netherlands.
Source: Contemporary clinical trials [Contemp Clin Trials] 2026 Aug; Vol. 167, pp. 108368. Date of Electronic Publication: 2026 Jun 04.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101242342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-2030 (Electronic) Linking ISSN: 15517144 NLM ISO Abbreviation: Contemp Clin Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22de+Wijs+I%22">de Wijs I</searchLink>; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain Cognition and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands. Electronic address: Imke.deWijs@radboudumc.nl.<br /><searchLink fieldCode="AU" term="%22Tendolkar+I%22">Tendolkar I</searchLink>; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain Cognition and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Beek+MHCT%22">van Beek MHCT</searchLink>; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain Cognition and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Belkum+S%22">van Belkum S</searchLink>; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Dalhuisen+I%22">Dalhuisen I</searchLink>; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain Cognition and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Dlabac-de+Lange+JJ%22">Dlabac-de Lange JJ</searchLink>; GGZ Centraal Mental Health Care, Amersfoort, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Eijndhoven+P%22">van Eijndhoven P</searchLink>; Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain Cognition and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Exel+E%22">van Exel E</searchLink>; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; GGZ inGeest Mental Health Care, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Houwert-Zuidema+M%22">Houwert-Zuidema M</searchLink>; GGZ Centraal Mental Health Care, Amersfoort, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Jeuring+HW%22">Jeuring HW</searchLink>; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kool+RB%22">Kool RB</searchLink>; Radboud University Medical Center, IQ Health Science Department, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Legemaat+A%22">Legemaat A</searchLink>; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Oostelbos+P%22">Oostelbos P</searchLink>; Depression Association, Randwijk, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rhebergen+D%22">Rhebergen D</searchLink>; GGZ Centraal Mental Health Care, Amersfoort, the Netherlands; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; GGZ inGeest Mental Health Care, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Velsen+H%22">van Velsen H</searchLink>; Focus Group Samen Sterker, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wijnen+B%22">Wijnen B</searchLink>; Centre for Economic Evaluation, Trimbos Institute (Netherlands Institute of Mental Health and Addiction), Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hendriks+GJ%22">Hendriks GJ</searchLink>; 'Overwaal' Centre of Expertise for Anxiety Disorders, OCD & PTSD, Pro Persona, Institute of Integrated Mental Health Care, Nijmegen, the Netherlands; Behavioral Science Institute, Radboud University, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Carlier+A%22">Carlier A</searchLink>; Behavioral Science Institute, Radboud University, Nijmegen, the Netherlands; Maria Mackenzie Expertise Center for Old Age Psychiatry, Pro Persona Mental Health Care, Nijmegen, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101242342%22">Contemporary clinical trials</searchLink> [Contemp Clin Trials] 2026 Aug; Vol. 167, pp. 108368. <i>Date of Electronic Publication: </i>2026 Jun 04.
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