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CD19/CD22 bivalent CAR T cells in children, adolescents and young adults with B-ALL: final phase 1 trial results.

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Title: CD19/CD22 bivalent CAR T cells in children, adolescents and young adults with B-ALL: final phase 1 trial results.
Authors: Silbert SK; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA., Gava F; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA., Yates B; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.; University of Colorado Denver Children's Hospital Colorado Research Institute, Aurora, Colorado, USA., Rankin AW; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.; Nationwide Children's Hospital, Columbus, Ohio, USA., Rocco JM; National Institute of Allergy and Infectious Disease, NIH, Bethesda, MD, USA., Shao L; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA., Dreyzin A; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA., Cai Y; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA., Lamplugh C; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA., Han KL; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA., Prochazkova M; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA., Little L; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA., Foley T; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA., Sankaran H; Biometric Research Program, National Cancer Institute, Bethesda, Maryland, USA., Martin K; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA., Garces P; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA., Jin P; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA., Chien CD; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA., Taylor N; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA., Fry TJ; University of Colorado Denver Children's Hospital Colorado Research Institute, Aurora, Colorado, USA., Yuan CM; Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA., Wang HW; Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA., Stroncek DF; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA., Highfill SL; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA., Shalabi H; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA., Shah NN; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA nirali.shah@nih.gov.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2026 Jun 05; Vol. 14 (6). Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: CD19/CD22 bivalent CAR T cells in children, adolescents and young adults with B-ALL: final phase 1 trial results.
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  Data: <searchLink fieldCode="AU" term="%22Silbert+SK%22">Silbert SK</searchLink>; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Gava+F%22">Gava F</searchLink>; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Yates+B%22">Yates B</searchLink>; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.; University of Colorado Denver Children's Hospital Colorado Research Institute, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Rankin+AW%22">Rankin AW</searchLink>; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.; Nationwide Children's Hospital, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Rocco+JM%22">Rocco JM</searchLink>; National Institute of Allergy and Infectious Disease, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Shao+L%22">Shao L</searchLink>; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Dreyzin+A%22">Dreyzin A</searchLink>; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Lamplugh+C%22">Lamplugh C</searchLink>; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Han+KL%22">Han KL</searchLink>; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Prochazkova+M%22">Prochazkova M</searchLink>; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Little+L%22">Little L</searchLink>; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Foley+T%22">Foley T</searchLink>; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Sankaran+H%22">Sankaran H</searchLink>; Biometric Research Program, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Martin+K%22">Martin K</searchLink>; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Garces+P%22">Garces P</searchLink>; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Jin+P%22">Jin P</searchLink>; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Chien+CD%22">Chien CD</searchLink>; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+N%22">Taylor N</searchLink>; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Fry+TJ%22">Fry TJ</searchLink>; University of Colorado Denver Children's Hospital Colorado Research Institute, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+CM%22">Yuan CM</searchLink>; Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Wang+HW%22">Wang HW</searchLink>; Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Stroncek+DF%22">Stroncek DF</searchLink>; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Highfill+SL%22">Highfill SL</searchLink>; Center for Cellular Engineering, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Shalabi+H%22">Shalabi H</searchLink>; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Shah+NN%22">Shah NN</searchLink>; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA nirali.shah@nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2026 Jun 05; Vol. 14 (6). <i>Date of Electronic Publication: </i>2026 Jun 05.
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  Data: Journal Article; Clinical Trial, Phase I
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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        Value: 10.1136/jitc-2026-015296
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        Text: English
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      – TitleFull: CD19/CD22 bivalent CAR T cells in children, adolescents and young adults with B-ALL: final phase 1 trial results.
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              Text: 2026 Jun 05
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