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Identification of a mechanism-based binding mode for a histone deacetylase 6 inhibitor.

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Title: Identification of a mechanism-based binding mode for a histone deacetylase 6 inhibitor.
Authors: Rodrigues DA; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland. danielalencar@rcsi.com.; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland. danielalencar@rcsi.com., Wang Y; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Department of Pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou, Jiangsu, China., Goulart Stollmaier J; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA, US., Sullivan GP; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland., D'Arcy C; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland., Coughlan AY; School of Medicine, University College Dublin, Dublin 4, Ireland., Roe A; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland., Bíró L; Department of Inorganic & Analytical Chemistry, Faculty of Science and Technology, University of Debrecen, Debrecen, Egyetem tér 1, Hungary., Watson PR; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA, US., Osko JD; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA, US., Twamley B; School of Chemistry, Trinity College Dublin, College Green, Dublin 2, Ireland., Wynne K; School of Biomolecular and Biomedical Science, Conway Institute of Biomedical and Biomolecular Sciences, University College Dublin, Dublin, Ireland.; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland., Cagney G; School of Biomolecular and Biomedical Science, Conway Institute of Biomedical and Biomolecular Sciences, University College Dublin, Dublin, Ireland., Buglyó P; Department of Inorganic & Analytical Chemistry, Faculty of Science and Technology, University of Debrecen, Debrecen, Egyetem tér 1, Hungary., Liu Y; Department of Pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou, Jiangsu, China., Griffith DM; Department of Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; SSPC, the Taighde Éireann- Research Ireland Centre for Pharmaceuticals, Limerick, Ireland., Christianson DW; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA, US., Chonghaile TN; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland. tnichonghaile@rcsi.com.; Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland. tnichonghaile@rcsi.com.
Source: Nature communications [Nat Commun] 2026 Jun 05. Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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