Targeting fibroblast TXNDC5 resolves tumor desmoplasia and PD-1 resistance in colorectal cancer with mesenchymal traits.

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Title: Targeting fibroblast TXNDC5 resolves tumor desmoplasia and PD-1 resistance in colorectal cancer with mesenchymal traits.
Authors: Cheng KL; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.; Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan., Chen CI; Division of Colon and Rectal Surgery, Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.; Division of General Surgery Medicine, Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.; School of Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan., Yu SH; Institute of Biotechnology, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan., Liang HW; Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan., Tsai YW; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan., Hung CT; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Lin YS; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Lee GH; International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan.; Department of Physiology, National Cheng Kung University, Tainan, Taiwan., Chen PY; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan., Tang MJ; International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan.; Department of Physiology, National Cheng Kung University, Tainan, Taiwan.; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan., Wu YF; Department of Research, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan., Lin SJ; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.; Department of Dermatology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan.; Center for Frontier Medicine, National Taiwan University Hospital, Taipei, Taiwan., Lee JK; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Yu LC; Graduate Institute and Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan., Lin SL; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan.; Graduate Institute and Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chen SY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Lee WC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Jeng YM; Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan., Huang RY; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Obstetrics & Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan., Chen RH; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.; Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan., Chen CC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Yang KC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan. kcyang@ntu.edu.tw.; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan. kcyang@ntu.edu.tw.; Center for Frontier Medicine, National Taiwan University Hospital, Taipei, Taiwan. kcyang@ntu.edu.tw.; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. kcyang@ntu.edu.tw.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. kcyang@ntu.edu.tw.
Source: Nature communications [Nat Commun] 2026 Jun 05; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-74073-1