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Targeting fibroblast TXNDC5 resolves tumor desmoplasia and PD-1 resistance in colorectal cancer with mesenchymal traits.

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Title: Targeting fibroblast TXNDC5 resolves tumor desmoplasia and PD-1 resistance in colorectal cancer with mesenchymal traits.
Authors: Cheng KL; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.; Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan., Chen CI; Division of Colon and Rectal Surgery, Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.; Division of General Surgery Medicine, Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.; School of Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan., Yu SH; Institute of Biotechnology, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan., Liang HW; Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan., Tsai YW; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan., Hung CT; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Lin YS; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Lee GH; International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan.; Department of Physiology, National Cheng Kung University, Tainan, Taiwan., Chen PY; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan., Tang MJ; International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan.; Department of Physiology, National Cheng Kung University, Tainan, Taiwan.; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan., Wu YF; Department of Research, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan., Lin SJ; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.; Department of Dermatology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan.; Center for Frontier Medicine, National Taiwan University Hospital, Taipei, Taiwan., Lee JK; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Yu LC; Graduate Institute and Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan., Lin SL; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan.; Graduate Institute and Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chen SY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Lee WC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Jeng YM; Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan., Huang RY; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Obstetrics & Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan., Chen RH; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.; Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan., Chen CC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Yang KC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan. kcyang@ntu.edu.tw.; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan. kcyang@ntu.edu.tw.; Center for Frontier Medicine, National Taiwan University Hospital, Taipei, Taiwan. kcyang@ntu.edu.tw.; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. kcyang@ntu.edu.tw.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. kcyang@ntu.edu.tw.
Source: Nature communications [Nat Commun] 2026 Jun 05; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Targeting fibroblast TXNDC5 resolves tumor desmoplasia and PD-1 resistance in colorectal cancer with mesenchymal traits.
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  Data: <searchLink fieldCode="AU" term="%22Cheng+KL%22">Cheng KL</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.; Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CI%22">Chen CI</searchLink>; Division of Colon and Rectal Surgery, Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.; Division of General Surgery Medicine, Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.; School of Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+SH%22">Yu SH</searchLink>; Institute of Biotechnology, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liang+HW%22">Liang HW</searchLink>; Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+YW%22">Tsai YW</searchLink>; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+CT%22">Hung CT</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Lin+YS%22">Lin YS</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+GH%22">Lee GH</searchLink>; International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan.; Department of Physiology, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+PY%22">Chen PY</searchLink>; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tang+MJ%22">Tang MJ</searchLink>; International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan.; Department of Physiology, National Cheng Kung University, Tainan, Taiwan.; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+YF%22">Wu YF</searchLink>; Department of Research, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SJ%22">Lin SJ</searchLink>; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.; Department of Dermatology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan.; Center for Frontier Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+JK%22">Lee JK</searchLink>; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+LC%22">Yu LC</searchLink>; Graduate Institute and Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SL%22">Lin SL</searchLink>; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan.; Graduate Institute and Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+SY%22">Chen SY</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+WC%22">Lee WC</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jeng+YM%22">Jeng YM</searchLink>; Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+RY%22">Huang RY</searchLink>; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Obstetrics & Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+RH%22">Chen RH</searchLink>; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.; Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CC%22">Chen CC</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+KC%22">Yang KC</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan. kcyang@ntu.edu.tw.; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan. kcyang@ntu.edu.tw.; Center for Frontier Medicine, National Taiwan University Hospital, Taipei, Taiwan. kcyang@ntu.edu.tw.; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. kcyang@ntu.edu.tw.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. kcyang@ntu.edu.tw.
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