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Optimal blood pressure target in patients with uncomplicated hypertension: a target trial emulation study.

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Title: Optimal blood pressure target in patients with uncomplicated hypertension: a target trial emulation study.
Authors: Zhang R; Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Lam ICH; Pharmaco- and Device Epidemiology, Health Data Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom., Emilsson L; Department of General Practice & General Practice Research Unit (AFE), Institute of Health and Society, University of Oslo, Oslo, Norway.; Vårdcentralen Nysäter and Centre for Clinical Research, County Council of Värmland, Värmland, Värmlands Nysäter, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden., Sun F; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China., Zhan S; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China., Yiu KH; Cardiology Division, Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Cardiology Division, Department of Medicine, The University of Hong Kong - Shenzhen Hospital, Shenzhen, China.; The Institute of Cardiovascular Science and Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Fong DYT; School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong SAR, Hong Kong, China., Yu EYT; Primary Healthcare Office, Health Bureau, Hong Kong SAR, China., Chui CSL; School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong SAR, Hong Kong, China.; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Chan EWY; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; The University of Hong Kong Shenzhen Institute of Research and Innovation, Hong Kong SAR, China., Wong ICK; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Aston Pharmacy School, Aston University, Birmingham, United Kingdom.; School of Pharmacy, Medical Sciences Division, Macau University of Science and Technology, Macau SAR, China.; Advanced Data Analytics for Medical Science Limited, Hong Kong SAR, China., Lam CLK; Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Department of Family Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China., Danaei G; Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.; CAUSALab, Department of Epidemiology, Harvard TH Chan School of Public Heath, Boston, Massachusetts, USA., Wan EYF; Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. yfwan@hku.hk.; The Institute of Cardiovascular Science and Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. yfwan@hku.hk.; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. yfwan@hku.hk.; Comprehensive Primary Healthcare Collaboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. yfwan@hku.hk.
Source: Nature communications [Nat Commun] 2026 Jun 05; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Lam+ICH%22">Lam ICH</searchLink>; Pharmaco- and Device Epidemiology, Health Data Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Emilsson+L%22">Emilsson L</searchLink>; Department of General Practice & General Practice Research Unit (AFE), Institute of Health and Society, University of Oslo, Oslo, Norway.; Vårdcentralen Nysäter and Centre for Clinical Research, County Council of Värmland, Värmland, Värmlands Nysäter, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Sun+F%22">Sun F</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhan+S%22">Zhan S</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yiu+KH%22">Yiu KH</searchLink>; Cardiology Division, Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Cardiology Division, Department of Medicine, The University of Hong Kong - Shenzhen Hospital, Shenzhen, China.; The Institute of Cardiovascular Science and Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Fong+DYT%22">Fong DYT</searchLink>; School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong SAR, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Yu+EYT%22">Yu EYT</searchLink>; Primary Healthcare Office, Health Bureau, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Chui+CSL%22">Chui CSL</searchLink>; School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong SAR, Hong Kong, China.; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Chan+EWY%22">Chan EWY</searchLink>; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; The University of Hong Kong Shenzhen Institute of Research and Innovation, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Wong+ICK%22">Wong ICK</searchLink>; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Aston Pharmacy School, Aston University, Birmingham, United Kingdom.; School of Pharmacy, Medical Sciences Division, Macau University of Science and Technology, Macau SAR, China.; Advanced Data Analytics for Medical Science Limited, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Lam+CLK%22">Lam CLK</searchLink>; Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Department of Family Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Danaei+G%22">Danaei G</searchLink>; Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.; CAUSALab, Department of Epidemiology, Harvard TH Chan School of Public Heath, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Wan+EYF%22">Wan EYF</searchLink>; Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. yfwan@hku.hk.; The Institute of Cardiovascular Science and Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. yfwan@hku.hk.; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. yfwan@hku.hk.; Comprehensive Primary Healthcare Collaboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. yfwan@hku.hk.
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