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Chronic low-dose iron exposure induces GPX4-mediated resistance to ferroptosis in a human chondrocyte cell line.

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Title: Chronic low-dose iron exposure induces GPX4-mediated resistance to ferroptosis in a human chondrocyte cell line.
Authors: Karim A; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates. akarim@sharjah.ac.ae.; Iron Biology Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. akarim@sharjah.ac.ae., Shafarin J; Iron Biology Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates., Suresh S; Iron Biology Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates., Muhammad JS; Department of Biomedical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom., Qaisar R; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.; Space Medicine Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates., Ahmad F; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.; Space Medicine Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates., Hamad M; Iron Biology Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. mabdelhaq@sharjah.ac.ae.; Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. mabdelhaq@sharjah.ac.ae.
Source: Cell and tissue research [Cell Tissue Res] 2026 Jun 06; Vol. 404 (3). Date of Electronic Publication: 2026 Jun 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417625 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0878 (Electronic) Linking ISSN: 0302766X NLM ISO Abbreviation: Cell Tissue Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0878
DOI:10.1007/s00441-026-04082-5