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Chronic low-dose iron exposure induces GPX4-mediated resistance to ferroptosis in a human chondrocyte cell line.

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Title: Chronic low-dose iron exposure induces GPX4-mediated resistance to ferroptosis in a human chondrocyte cell line.
Authors: Karim A; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates. akarim@sharjah.ac.ae.; Iron Biology Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. akarim@sharjah.ac.ae., Shafarin J; Iron Biology Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates., Suresh S; Iron Biology Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates., Muhammad JS; Department of Biomedical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom., Qaisar R; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.; Space Medicine Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates., Ahmad F; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.; Space Medicine Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates., Hamad M; Iron Biology Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. mabdelhaq@sharjah.ac.ae.; Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. mabdelhaq@sharjah.ac.ae.
Source: Cell and tissue research [Cell Tissue Res] 2026 Jun 06; Vol. 404 (3). Date of Electronic Publication: 2026 Jun 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417625 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0878 (Electronic) Linking ISSN: 0302766X NLM ISO Abbreviation: Cell Tissue Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chronic low-dose iron exposure induces GPX4-mediated resistance to ferroptosis in a human chondrocyte cell line.
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  Data: <searchLink fieldCode="AU" term="%22Karim+A%22">Karim A</searchLink>; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates. akarim@sharjah.ac.ae.; Iron Biology Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. akarim@sharjah.ac.ae.<br /><searchLink fieldCode="AU" term="%22Shafarin+J%22">Shafarin J</searchLink>; Iron Biology Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Suresh+S%22">Suresh S</searchLink>; Iron Biology Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Muhammad+JS%22">Muhammad JS</searchLink>; Department of Biomedical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Qaisar+R%22">Qaisar R</searchLink>; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.; Space Medicine Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Ahmad+F%22">Ahmad F</searchLink>; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Cardiovascular Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.; Space Medicine Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Hamad+M%22">Hamad M</searchLink>; Iron Biology Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. mabdelhaq@sharjah.ac.ae.; Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. mabdelhaq@sharjah.ac.ae.
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  Data: <searchLink fieldCode="JN" term="%220417625%22">Cell and tissue research</searchLink> [Cell Tissue Res] 2026 Jun 06; Vol. 404 (3). <i>Date of Electronic Publication: </i>2026 Jun 06.
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        Value: 10.1007/s00441-026-04082-5
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      – Code: eng
        Text: English
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      – TitleFull: Chronic low-dose iron exposure induces GPX4-mediated resistance to ferroptosis in a human chondrocyte cell line.
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              Text: 2026 Jun 06
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              Y: 2026
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