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Licochalcone a enhances cognitive resilience in APP/PS1 Mice by modulating glucose metabolism, Aβ burden, and neuroinflammation.

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Title: Licochalcone a enhances cognitive resilience in APP/PS1 Mice by modulating glucose metabolism, Aβ burden, and neuroinflammation.
Authors: Carrasco M; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain., Guzman L; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain., Barroso E; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain., Olloquequi J; Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedical Sciences, Faculty of Health Sciences, Universidad Autónoma de Chile, Talca, Chile., Cano A; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain., Ureña J; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain.; Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028, Barcelona, Spain., Verdaguer E; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain.; Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028, Barcelona, Spain., Prohens R; Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Avda. Joan XXIII, 08028, Barcelona, Spain.; Center for Intelligent Research in Crystal Engineering S.L., Parc Científic de Barcelona, Baldiri Reixac, 4-8, 08028, Barcelona, Spain., Fortuna A; Laboratory of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, 3000-548, Coimbra, Portugal.; Coimbra Institute for Biomedical Imaging and Translational Research, CIBIT/ICNAS, University of Coimbra, 3000-548, Coimbra, Portugal., Auladell C; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain.; Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028, Barcelona, Spain., Ettcheto M; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain. mirenettcheto@ub.edu.; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. mirenettcheto@ub.edu.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain. mirenettcheto@ub.edu.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain. mirenettcheto@ub.edu., Camins A; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.
Source: GeroScience [Geroscience] 2026 Jun 06. Date of Electronic Publication: 2026 Jun 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
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  Data: Licochalcone a enhances cognitive resilience in APP/PS1 Mice by modulating glucose metabolism, Aβ burden, and neuroinflammation.
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  Data: <searchLink fieldCode="AU" term="%22Carrasco+M%22">Carrasco M</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.<br /><searchLink fieldCode="AU" term="%22Guzman+L%22">Guzman L</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Barroso+E%22">Barroso E</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Olloquequi+J%22">Olloquequi J</searchLink>; Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Institute of Biomedical Sciences, Faculty of Health Sciences, Universidad Autónoma de Chile, Talca, Chile.<br /><searchLink fieldCode="AU" term="%22Cano+A%22">Cano A</searchLink>; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ureña+J%22">Ureña J</searchLink>; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain.; Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Verdaguer+E%22">Verdaguer E</searchLink>; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain.; Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Prohens+R%22">Prohens R</searchLink>; Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Avda. Joan XXIII, 08028, Barcelona, Spain.; Center for Intelligent Research in Crystal Engineering S.L., Parc Científic de Barcelona, Baldiri Reixac, 4-8, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fortuna+A%22">Fortuna A</searchLink>; Laboratory of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, 3000-548, Coimbra, Portugal.; Coimbra Institute for Biomedical Imaging and Translational Research, CIBIT/ICNAS, University of Coimbra, 3000-548, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Auladell+C%22">Auladell C</searchLink>; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain.; Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ettcheto+M%22">Ettcheto M</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain. mirenettcheto@ub.edu.; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. mirenettcheto@ub.edu.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain. mirenettcheto@ub.edu.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain. mirenettcheto@ub.edu.<br /><searchLink fieldCode="AU" term="%22Camins+A%22">Camins A</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, 08028, Barcelona, Spain.; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Neuroscience, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.
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