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Plasma small RNA profiling reveals a three-miRNA signature associated with early beta cell dysfunction across glucose tolerance stages.

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Title: Plasma small RNA profiling reveals a three-miRNA signature associated with early beta cell dysfunction across glucose tolerance stages.
Authors: Aiello E; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.; Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, Siena, Italy., Grieco GE; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.; Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, Siena, Italy., Brunetti M; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Endocrinology, Diabetes and Internal Medicine, Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy., Gliozzo G; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy., Fignani D; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.; Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, Siena, Italy., Quero G; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Chirurgia Digestiva, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy., Alfieri S; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Chirurgia Digestiva, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy., Di Giuseppe G; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Endocrinology, Diabetes and Internal Medicine, Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy., Ciccarelli G; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Endocrinology, Diabetes and Internal Medicine, Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy., Dardano A; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Parenti M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Mari A; Institute of Neuroscience, National Research Council, Padova, Italy., Bizzotto R; Institute of Neuroscience, National Research Council, Padova, Italy., Daniele G; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Giaccari A; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Endocrinology, Diabetes and Internal Medicine, Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy., Dotta F; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy. francesco.dotta@unisi.it.; Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, Siena, Italy. francesco.dotta@unisi.it.; Department of Biomedical Sciences, National Research Council, Rome, Italy. francesco.dotta@unisi.it., Sebastiani G; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.; Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, Siena, Italy.; Tuscany Centre for Precision Medicine (CReMeP), Siena, Italy., Mezza T; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Endocrinology, Diabetes and Internal Medicine, Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy.
Source: Diabetologia [Diabetologia] 2026 Sep; Vol. 69 (9), pp. 2620-2633. Date of Electronic Publication: 2026 Jun 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
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  Data: Plasma small RNA profiling reveals a three-miRNA signature associated with early beta cell dysfunction across glucose tolerance stages.
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  Data: <searchLink fieldCode="AU" term="%22Aiello+E%22">Aiello E</searchLink>; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.; Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Grieco+GE%22">Grieco GE</searchLink>; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.; Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Brunetti+M%22">Brunetti M</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Endocrinology, Diabetes and Internal Medicine, Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Gliozzo+G%22">Gliozzo G</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fignani+D%22">Fignani D</searchLink>; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.; Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Quero+G%22">Quero G</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Chirurgia Digestiva, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Alfieri+S%22">Alfieri S</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Chirurgia Digestiva, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Giuseppe+G%22">Di Giuseppe G</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Endocrinology, Diabetes and Internal Medicine, Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Ciccarelli+G%22">Ciccarelli G</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Endocrinology, Diabetes and Internal Medicine, Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Dardano+A%22">Dardano A</searchLink>; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Parenti+M%22">Parenti M</searchLink>; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Mari+A%22">Mari A</searchLink>; Institute of Neuroscience, National Research Council, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Bizzotto+R%22">Bizzotto R</searchLink>; Institute of Neuroscience, National Research Council, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Daniele+G%22">Daniele G</searchLink>; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Giaccari+A%22">Giaccari A</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Endocrinology, Diabetes and Internal Medicine, Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Dotta+F%22">Dotta F</searchLink>; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy. francesco.dotta@unisi.it.; Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, Siena, Italy. francesco.dotta@unisi.it.; Department of Biomedical Sciences, National Research Council, Rome, Italy. francesco.dotta@unisi.it.<br /><searchLink fieldCode="AU" term="%22Sebastiani+G%22">Sebastiani G</searchLink>; Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.; Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, Siena, Italy.; Tuscany Centre for Precision Medicine (CReMeP), Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Mezza+T%22">Mezza T</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Endocrinology, Diabetes and Internal Medicine, Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy.
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  Data: <searchLink fieldCode="JN" term="%220006777%22">Diabetologia</searchLink> [Diabetologia] 2026 Sep; Vol. 69 (9), pp. 2620-2633. <i>Date of Electronic Publication: </i>2026 Jun 06.
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